Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | citalopram raises basal extracellular serotonin levels in DBA/2J, DBA/2N and BALB/c mice carrying the 1473G allele, but not in C57BL/6J and C57BL/6N mice carrying the 1473C allele, overview | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
G1473C | naturally occuring polymorphism, citalopram raises basal extracellular serotonin levels in DBA/2J, DBA/2N and BALB/c mice carrying the 1473G allele, but not in C57BL/6J and C57BL/6N mice carrying the 1473C allele, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Mus musculus | rate-limiting step in serotonin, i.e. 5-hydroxytryptamine, biosynthesis | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
DBA/2J, DBA/2N and BALB/c mice carrying the 1473G allele, and C57BL/6J and C57BL/6N mice carrying the 1473C allele | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | prefrontal cortex and dorsal hippocampus | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
determination of extracellular 4-hydroxytryptamine | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | - |
Mus musculus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | rate-limiting step in serotonin, i.e. 5-hydroxytryptamine, biosynthesis | Mus musculus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPH2 | - |
Mus musculus |
tryptophan hydroxylase-2 | - |
Mus musculus |