Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | TPH2 is upregulated by dominant-negative RE-1 silencer of transcription, minimum of 4.4fold relative to hypoxanthine-guanine phosphoribosyltransferase, overview | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
gene TPH2, DNA and amino acid sequence determination, analysis of the TPH2 promoter and bipartite NRSE motif, a transcription element in the TPH2 promoter, a bipartite variant interrupted by a 6-base insertion, that resembles the binding motif for RE-1 silencer of transcription, i.e. REST, also known as NRSF transcription factor, quantitative reverse transcription-PCR expression analysis, sequence comparisons | Rattus norvegicus |
gene TPH2, DNA and amino acid sequence determination, identification of a transcription element in the TPH2 promoter, a bipartite variant interrupted by a 6-base insertion, that resembles the binding motif for RE-1 silencer of transcription, i.e. REST, also known as NRSF transcription factor, permutations of the motif reveal considerable flexibility in the juxtaposition of the two halves of bipartite NRSE, expressionin rat C6-glioma cells, quantitative reverse transcription-PCR expression analysis, sequence comparisons | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Rattus norvegicus | TPH2 is the rate-limiting enzyme in raphe serotonin biosynthesis | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | Homo sapiens | TPH2 is the rate-limiting enzyme in raphe serotonin biosynthesis, and polymorphisms of TPH2 are implicated in vulnerability to psychiatric disorders | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
additional information | Homo sapiens | TPH2 expression is part of the developmental program regulated by REST, i.e. the RE-1 silencer of transcription, REST/NRSF is implicated in neurogenesis and transcriptionally regulates a network of genes, overview | ? | - |
? | |
additional information | Rattus norvegicus | TPH2 expression is part of the developmental program regulated by REST, i.e. the RE-1 silencer of transcription, REST/NRSF is implicated in neurogenesis and transcriptionally regulates a network of genes, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8IWU9 | gene TPH2 | - |
Rattus norvegicus | Q8CGU9 | gene TPH2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C6 glioma cell | - |
Rattus norvegicus | - |
glioma cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | - |
Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | TPH2 is the rate-limiting enzyme in raphe serotonin biosynthesis | Rattus norvegicus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | TPH2 is the rate-limiting enzyme in raphe serotonin biosynthesis, and polymorphisms of TPH2 are implicated in vulnerability to psychiatric disorders | Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
additional information | TPH2 expression is part of the developmental program regulated by REST, i.e. the RE-1 silencer of transcription, REST/NRSF is implicated in neurogenesis and transcriptionally regulates a network of genes, overview | Homo sapiens | ? | - |
? | |
additional information | TPH2 expression is part of the developmental program regulated by REST, i.e. the RE-1 silencer of transcription, REST/NRSF is implicated in neurogenesis and transcriptionally regulates a network of genes, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPH2 | - |
Homo sapiens |
TPH2 | - |
Rattus norvegicus |
tryptophan hydroxylase-2 | - |
Homo sapiens |
tryptophan hydroxylase-2 | - |
Rattus norvegicus |