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Literature summary for 1.14.16.4 extracted from

  • Gacek, P.; Conner, T.S.; Tennen, H.; Kranzler, H.R.; Covault, J.
    Tryptophan hydroxylase 2 gene and alcohol use among college students (2008), Addict. Biol., 13, 440-448.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.16.4

Cloned(Commentary)

Cloned (Comment) Organism
TPH1 and TPH2 genotyping Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information G703T and C218A are naturally occuring polymorphisms, genotyping of TPH1 and TPH2 in correlation to alcohol abuse, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Homo sapiens the enzyme is rate limiting in serotonin biosynthesis and important in serotonergic neurotransmission, overview 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
additional information Homo sapiens alcohol consumption may influence TPH1 and TPH2 expression and regulation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P17752
-
-

Source Tissue

Source Tissue Comment Organism Textmining
midbrain
-
 Homo sapiens
-
neuron serotonergic Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
-
 Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
L-tryptophan + tetrahydrobiopterin + O2 the enzyme is rate limiting in serotonin biosynthesis and important in serotonergic neurotransmission, overview Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
additional information alcohol consumption may influence TPH1 and TPH2 expression and regulation Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
TPH1
-
 Homo sapiens
TPH2
-
 Homo sapiens
tryptophan hydroxylase 1
-
 Homo sapiens
tryptophan hydroxylase 2
-
 Homo sapiens