Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.16.4 extracted from

  • Cervo, L.; Canetta, A.; Calcagno, E.; Burbassi, S.; Sacchetti, G.; Caccia, S.; Fracasso, C.; Albani, D.; Forloni, G.; Invernizzi, R.W.
    Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression (2005), J. Neurosci., 25, 8165-8172.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 Mus musculus
-
5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain the selective serotonin reuptake inhibitor citalopram has no effect in mice strain that exhibit a reduced 5-hydroxy-L-tryptophan synthesis due to a mutatation in the tryptophan hydroxylase 2 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2
-
Mus musculus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Synonyms

Synonyms Comment Organism
TPH2
-
Mus musculus
tryptophan hydroxylase 2
-
Mus musculus