Literature summary for 1.14.16.2 extracted from

Parra, L.A.; Baust, T.B.; Smith, A.D.; Jaumotte, J.D.; Zigmond, M.J.; Torres, S.; Leak, R.K.; Pino, J.A.; Torres, G.E.
The molecular chaperone Hsc70 interacts with tyrosine hydroxylase to regulate enzyme activity and synaptic vesicle localization (2016), J. Biol. Chem., 291, 17510-17522 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
Hsc70	Hsc70 physically and functionally interacts with TH to regulate the enzyme activity and synaptic vesicle targeting	Rattus norvegicus
Hsc70	Hsc70 physically and functionally interacts with TH to regulate the enzyme activity and synaptic vesicle targeting	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
vesicle	-	Rattus norvegicus	31982	-
vesicle	-	Mus musculus	31982	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-tyrosine + tetrahydrobiopterin + O2	Rattus norvegicus	-	L-dopa + 4a-hydroxytetrahydrobiopterin + H2O	-	?
L-tyrosine + tetrahydrobiopterin + O2	Mus musculus	-	L-dopa + 4a-hydroxytetrahydrobiopterin + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P24529	-	-
Rattus norvegicus	P04177	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-NTA column chromatography	Rattus norvegicus
Ni-NTA column chromatography	Mus musculus

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-
brain	-	Mus musculus	-
dopaminergic neuron	-	Rattus norvegicus	-
dopaminergic neuron	-	Mus musculus	-
midbrain	-	Rattus norvegicus	-
midbrain	-	Mus musculus	-
MN9D cell	-	Mus musculus	-
striatum	-	Rattus norvegicus	-
striatum	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tyrosine + tetrahydrobiopterin + O2	-	Rattus norvegicus	L-dopa + 4a-hydroxytetrahydrobiopterin + H2O	-	?
L-tyrosine + tetrahydrobiopterin + O2	-	Mus musculus	L-dopa + 4a-hydroxytetrahydrobiopterin + H2O	-	?

Synonyms

Synonyms	Comment	Organism
tyrosine hydroxylase	-	Rattus norvegicus
tyrosine hydroxylase	-	Mus musculus

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Release 2023.1 (January 2023)