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Literature summary for 1.14.16.2 extracted from

  • Ghorbani, S.; Fossbakk, A.; Jorge-Finnigan, A.; Flydal, M.I.; Haavik, J.; Kleppe, R.
    Regulation of tyrosine hydroxylase is preserved across different homo- and heterodimeric 14-3-3 proteins (2016), Amino Acids, 48, 1221-1229 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
14-3-3gamma homodimeric 14-3-3gamma protein is the strongest activator Homo sapiens
14-3-3gamma protein homodimeric 14-3-3gamma protein is the strongest activator Bos taurus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 Codon Plus (DE3) cells Bos taurus
expressed in Escherichia coli BL21 Codon Plus (DE3) cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2 Bos taurus
-
L-dopa + 4a-hydroxytetrahydrobiopterin + H2O
-
?
L-tyrosine + tetrahydrobiopterin + O2 Homo sapiens
-
L-dopa + 4a-hydroxytetrahydrobiopterin + H2O
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens P07101
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation at Ser19 Bos taurus
phosphoprotein phosphorylation at Ser19 Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography and Superdex 200 gel filtration Bos taurus
Ni-NTA column chromatography and Superdex 200 gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2
-
Bos taurus L-dopa + 4a-hydroxytetrahydrobiopterin + H2O
-
?
L-tyrosine + tetrahydrobiopterin + O2
-
Homo sapiens L-dopa + 4a-hydroxytetrahydrobiopterin + H2O
-
?

Synonyms

Synonyms Comment Organism
tyrosine hydroxylase
-
Bos taurus
tyrosine hydroxylase
-
Homo sapiens