Cloned (Comment) | Organism |
---|---|
expressed in monkey striatum using harmless adeno-associated virus vectors and in PC-12 cells and AtT-20 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | the deletion mutation of N-terminal 38-amino acids increases the binding capacity of 5,6,7,8,-tetrahydrobiopterin to tyrosine hydroxylase molecule to increase the activity and possibly to increase the stability | Homo sapiens |
R37E/R38E | the point mutation increases the binding capacity of 5,6,7,8,-tetrahydrobiopterin to tyrosine hydroxylase molecule to increase the activity and possibly to increase the stability | Homo sapiens |
General Stability | Organism |
---|---|
the 14-3-3eta protein regulates tyrosine hydroxylase type 1 stability against degradation by acting on the N-terminus | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
adrenaline | - |
Homo sapiens | |
dopamine | - |
Homo sapiens | |
noradrenaline | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | Ser31 and Ser40 are readily phosphorylated to activate tyrosine hydroxylase type 1 in vitro. Although phosphorylation of Ser19 does not directly activate tyrosine hydroxylase, chaperone 14-3-3 protein binds and activates tyrosine hydroxylase at Ser19 phosphorylated by Ca2+/calmodulin-dependent protein kinase II. | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + 5,6,7,8-tetrahydro-L-biopterin + O2 | - |
Homo sapiens | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydro-L-biopterin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TH1 | isoform | Homo sapiens |
tyrosine hydroxylase | - |
Homo sapiens |
tyrosine hydroxylase type 1 | isoform | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
5,6,7,8-tetrahydro-L-biopterin | - |
Homo sapiens |