Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal medulla | - |
Rattus norvegicus | - |
brain | - |
Rattus norvegicus | - |
neuron | mid brain dopamine neuron | Rattus norvegicus | - |
PC-12 cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tyrosine hydroxylase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
tetrahydrobiopterin | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | neither forskolin, nor phorbol esters or stimulatory agonists like glutamate, neurotensin, muscarine, nicotine or pituitary adenylate cyclase-activating peptide reproducibly induce tyrosine hydroxylase mRNA in the midbrain. When midbrain slices are treated with 1 mM 8-(4-chlorophenylthio)-cAMP or 0.01 mM forskolin, there is no induction of tyrosine hydroxylase mRNA. | additional information |
Rattus norvegicus | long-term stress from hypoxia leads to induction of tyrosine hydroxylase mRNA and protein in adrenal medulla and brain, this induction is usually associated with stimulation of tyrosine hydroxylase gene transcription rate. Tyrosine hydroxylase mRNA increases 8fold at 3 h after immobilization of rats and remains elevated about 2fold after 24 h. Tyrosine hydroxylase gene transcription increases in response to nicotine or stress. cAMP is a powerful inducer of both tyrosine hydroxylase mRNA and protein. | up |