Activating Compound | Comment | Organism | Structure |
---|---|---|---|
L-Dopa | L-DOPA treatment (20-200 microM) increases the levels of dopamine by 226%-504% after 3-6 h of treatment and enhances the activities of tyrosine hydroxylase and aromatic L-amino acid decarboxylase | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-Dopa | Increased levels of intracellular L-DOPA inhibits tyrosine hydroxylase activity by end-product inhibition at early time points, L-DOPA (20-200 microM) treatment leads to a 562%-937% increase in L-DOPA influx at 1 h, which inhibits the activity of tyrosine hydroylase during the same period. | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydropteridine + O2 | Rattus norvegicus | - |
3,4-dihydroxyphenylalanine + dihydropteridine + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
PC-12 cell | derived from a pheochromocytoma of the rat adrenal medulla | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
217% activity compared to control level, treatment with 0.02 mM L-DOPA in PC-12 cells at 6 h time point | Rattus norvegicus |
additional information | - |
232% activity compared to control level, treatment with 0.1 mM L-DOPA in PC-12 cells at 6 h time point | Rattus norvegicus |
additional information | - |
272% activity compared to control level, treatment with 0.02 mM L-DOPA in PC-12 cells at 6 h time point | Rattus norvegicus |
additional information | - |
55.2% activity compared to control level, treatment with 0.2 mM L-DOPA in PC-12 cells at 48 h time point | Rattus norvegicus |
additional information | - |
62.6% activity compared to control level, treatment with 0.2 mM L-DOPA in PC-12 cells at 1 h time point | Rattus norvegicus |
additional information | - |
68.2% activity compared to control level, treatment with 0.1 mM L-DOPA in PC-12 cells at 1 h time point | Rattus norvegicus |
additional information | - |
82.2% activity of tyrosine hydroxylase compared to control level, treatment with 0.02 mM L-DOPA in PC-12 cells at 1 h time point | Rattus norvegicus |
additional information | - |
82.3% activity compared to control level, treatment with 0.1 mM L-DOPA in PC-12 cells at 48 h time point | Rattus norvegicus |
additional information | - |
activity returns to the control level between 24-48 h after treatment with 0.02 mM L-DOPA. | Rattus norvegicus |
0.00368 | - |
activity of tyrosine hydroxylase, control level without treatment of L-DOPA in PC-12 cells | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydropteridine + O2 | - |
Rattus norvegicus | 3,4-dihydroxyphenylalanine + dihydropteridine + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tyrosine hydroxylase | - |
Rattus norvegicus |