Literature summary for 1.14.16.2 extracted from

Roma, J.; Saus, E.; Cuadros, M.; Reventos, J.; Sanchez de Toledo, J.; Gallego, S.
Characterisation of novel splicing variants of the tyrosine hydroxylase C-terminal domain in human neuroblastic tumours (2007), Biol. Chem., 388, 419-426.

Search for more literature for 1.14.16.2

Cloned(Commentary)

Cloned (Comment)	Organism
isozyme DNA and amino acid sequence determination and analysis, RT-PCR analysis of isozyme expression in neuroblastoma tumors, in abdominal and thoracic tumours and foetal adrenal glands, using external and internal primers, 4.0fold lower expression level in adrenal glands than in abdominal tumors, overview, expression of the enzyme mutant lacking exons 2, 8, and 9 in HeLa cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of a truncation enzyme mutant lacking exons 2, 8, and 9 and showing reduced enzyme activity	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-tyrosine + tetrahydrobiopterin + O2	Homo sapiens	rate-limiting enzyme of the catecholamine biosynthesis	3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isozyme TH-1 to TH-4	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuroblastoma cell	37 different tumor samples, analysis of enzyme expression	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tyrosine + tetrahydrobiopterin + O2	-	Homo sapiens	3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O	-	?
L-tyrosine + tetrahydrobiopterin + O2	rate-limiting enzyme of the catecholamine biosynthesis	Homo sapiens	3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O	-	?

Subunits

Subunits	Comment	Organism
?	x * 58000-62000, tyrosine hydroxylase isozymes, SDS-PAGE, identification by mass spectrometry	Homo sapiens

Synonyms

Synonyms	Comment	Organism
tyrosine hydroxylase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
tetrahydrobiopterin	-	Homo sapiens

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Release 2023.1 (January 2023)