Cloned (Comment) | Organism |
---|---|
isozyme DNA and amino acid sequence determination and analysis, RT-PCR analysis of isozyme expression in neuroblastoma tumors, in abdominal and thoracic tumours and foetal adrenal glands, using external and internal primers, 4.0fold lower expression level in adrenal glands than in abdominal tumors, overview, expression of the enzyme mutant lacking exons 2, 8, and 9 in HeLa cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a truncation enzyme mutant lacking exons 2, 8, and 9 and showing reduced enzyme activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | Homo sapiens | rate-limiting enzyme of the catecholamine biosynthesis | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme TH-1 to TH-4 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuroblastoma cell | 37 different tumor samples, analysis of enzyme expression | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | - |
Homo sapiens | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? | |
L-tyrosine + tetrahydrobiopterin + O2 | rate-limiting enzyme of the catecholamine biosynthesis | Homo sapiens | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 58000-62000, tyrosine hydroxylase isozymes, SDS-PAGE, identification by mass spectrometry | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
tyrosine hydroxylase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
tetrahydrobiopterin | - |
Homo sapiens |