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Literature summary for 1.14.16.2 extracted from

  • Chaube, R.; Joy, K.P.
    Estrogen regulation of in vitro brain tyrosine hydroxylase activity in the catfish Heteropneustes fossilis: interactions with cAMP-protein kinase A and protein kinase C systems in enzyme activation (2005), Gen. Comp. Endocrinol., 141, 116-125.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
1-methyl-3-isobutylxanthine 1.5 mM Heteropneustes fossilis
adenosine 3',5' cyclic monophosphate 1 mM Heteropneustes fossilis
estradiol-17beta activating at concetration below 0.5 mM Heteropneustes fossilis
theophylline 1.5 mM Heteropneustes fossilis

Inhibitors

Inhibitors Comment Organism Structure
estradiol-17beta inhibiting at concetration above 0.5 mM. adenosine 3',5' cyclic monophosphate enhances the inhibition at high estradiol-17beta concentrations Heteropneustes fossilis
additional information inhibition of cAMP-protein kinase A and protein kinase C in crude extracts significantly reduces tyrosine hydroxylase activity Heteropneustes fossilis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0001
-
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine telencephalon extract, 10 microM estadriol-17beta, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C Heteropneustes fossilis
0.00015
-
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine telencephalon extract, 1 microM estadriol-17beta, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C Heteropneustes fossilis
0.0002
-
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine hypothalamus extract, 10 microM estadriol-17beta, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C Heteropneustes fossilis
0.0002
-
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine telencephalon extract, 1 nM estadriol-17beta, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C Heteropneustes fossilis
0.00022
-
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine hypothalamus extract, 1 nM estadriol-17beta, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C Heteropneustes fossilis
0.00024
-
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine hypothalamus extract, 1 microM estadriol-17beta, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C Heteropneustes fossilis
0.00024
-
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine telencephalon extract, 1 fM estadriol-17beta, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C Heteropneustes fossilis
0.00026
-
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine hypothalamus extract, 1 fM estadriol-17beta, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C Heteropneustes fossilis
0.00034
-
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine hypothalamus extract, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C Heteropneustes fossilis
0.00035
-
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine telencephalon extract, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C Heteropneustes fossilis
0.00045
-
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine hypothalamus extract, 0.01 mM estadriol-17beta, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C Heteropneustes fossilis
0.00048
-
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine telencephalon extract, 0.01 mM estadriol-17beta, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C Heteropneustes fossilis
0.00054
-
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine telencephalon extract, 1 mM estadriol-17beta, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C Heteropneustes fossilis
0.00058
-
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine hypothalamus extract, 1 mM estadriol-17beta, 0.1-0.5 mM L-tyrosine, 1-8 mM 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine, PBS buffer pH 6.2, 2-mercaptoethanol, catalase, 30°C Heteropneustes fossilis

Organism

Organism UniProt Comment Textmining
Heteropneustes fossilis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hypothalamus
-
Heteropneustes fossilis
-
telencephalon
-
Heteropneustes fossilis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine + O2
-
Heteropneustes fossilis ?
-
?

Synonyms

Synonyms Comment Organism
TH
-
Heteropneustes fossilis
tyrosine hydroxylase
-
Heteropneustes fossilis