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Literature summary for 1.14.16.2 extracted from

  • Hamdan, F.F.; Ribeiro, P.
    Cloning and characterization of a novel form of tyrosine hydroxylase from the human parasite, Schistosoma mansoni (1998), J. Neurochem., 71, 1369-1380.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression as His-tagged protein in Escherichia coli, amino acid sequence analysis Schistosoma mansoni

Inhibitors

Inhibitors Comment Organism Structure
Catecholamines
-
Schistosoma mansoni
tyrosine at concentrations above 0.03 mM Schistosoma mansoni

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0095
-
tyrosine
-
Schistosoma mansoni
0.045
-
tetrahydrobiopterin
-
Schistosoma mansoni

Organism

Organism UniProt Comment Textmining
Schistosoma mansoni
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant from Escherichia coli Schistosoma mansoni

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00003
-
crude extract Schistosoma mansoni
0.78
-
purified enzyme Schistosoma mansoni

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2 tetrahydropterin absolutely required Schistosoma mansoni 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O 3,4-dihydroxy-L-phenylalanine is identical with dopa ?
L-tyrosine + tetrahydrobiopterin + O2
-
Schistosoma mansoni L-dopa + 4a-hydroxytetrahydrobiopterin + H2O
-
r

Synonyms

Synonyms Comment Organism
TH
-
Schistosoma mansoni