Activating Compound | Comment | Organism | Structure |
---|---|---|---|
L-phenylalanine | - |
Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
A47G | the mutation decreases the affinity of the catalytic domain for L-phenylalanine compared to the wild type | Rattus norvegicus |
E44Q | the mutation decreases the affinity of the catalytic domain for L-phenylalanine compared to the wild type and leads to loss of activity | Rattus norvegicus |
H64N | the mutation decreases the affinity of the catalytic domain for L-phenylalanine compared to the wild type | Rattus norvegicus |
L48V | the mutation decreases the affinity of the catalytic domain for L-phenylalanine compared to the wild type | Rattus norvegicus |
L62V | the mutation decreases the affinity of the catalytic domain for L-phenylalanine compared to the wild type and leads to loss of activity | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-phenylalanine + tetrahydrobiopterin + O2 | Rattus norvegicus | - |
L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P04176 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-phenylalanine + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PheH | - |
Rattus norvegicus |
phenylalanine hydroxylase | - |
Rattus norvegicus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.2 | - |
L-phenylalanine | mutant enzyme L48V, at pH 7.0 and 23°C | Rattus norvegicus | |
5.8 | - |
L-phenylalanine | mutant enzyme A47G, at pH 7.0 and 23°C | Rattus norvegicus | |
6.5 | - |
L-phenylalanine | mutant enzyme H64N, at pH 7.0 and 23°C | Rattus norvegicus | |
9.7 | - |
L-phenylalanine | wild type enzyme, at pH 7.0 and 23°C | Rattus norvegicus |