Protein Variants | Comment | Organism |
---|---|---|
G33A | increased basal activity, reduced activation by preincubation with substrate | Homo sapiens |
G33V | increased basal activity, reduced activation by preincubation with substrate | Homo sapiens |
K113P | increased basal activity, reduced activation by preincubation with substrate, increase in positive cooperativity | Homo sapiens |
N223D | low basal activity, little activation by preincubation with substrate, increase in positive cooperativity | Homo sapiens |
N32D | low basal activity, close to normal activation by preincubation with substrate | Homo sapiens |
N426D | low basal activity, close to normal activation by preincubation with substrate | Homo sapiens |
T427P | low basal activity, little activation by preincubation with substrate, no kinetic cooperativity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00439 | - |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.98 | - |
substrate L-phenylalanine, mutant N223D | Homo sapiens |
2.34 | - |
substrate tetrahydrobiopterin, mutant N223D | Homo sapiens |
2.84 | - |
substrate tetrahydrobiopterin, mutant T427P | Homo sapiens |
3.17 | - |
substrate L-phenylalanine, mutant T427P | Homo sapiens |
3.48 | - |
substrate L-phenylalanine, wild-type | Homo sapiens |
3.67 | - |
substrate L-phenylalanine, mutant N426D | Homo sapiens |
3.74 | - |
substrate L-phenylalanine, mutant N32D | Homo sapiens |
4.37 | - |
substrate L-phenylalanine, mutant G33A | Homo sapiens |
4.39 | - |
substrate tetrahydrobiopterin, mutant N426D | Homo sapiens |
4.73 | - |
substrate tetrahydrobiopterin, mutant G33A | Homo sapiens |
4.73 | - |
substrate tetrahydrobiopterin, mutant N32D | Homo sapiens |
5.16 | - |
substrate L-phenylalanine, mutant G33V | Homo sapiens |
5.32 | - |
substrate tetrahydrobiopterin, wild-type | Homo sapiens |
6.19 | - |
substrate L-phenylalanine, mutant K113P | Homo sapiens |
6.41 | - |
substrate tetrahydrobiopterin, mutant G33V | Homo sapiens |
8.56 | - |
substrate tetrahydrobiopterin, mutant K113P | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-phenylalanine + tetrahydrobiopterin + O2 | - |
Homo sapiens | L-tyrosine + dihydrobiopterin + H2O | - |
? |