Literature summary for 1.14.16.1 extracted from

Andreas Andersen, O.; Flatmark, T.; Hough, E.
Crystal structure of the ternary complex of the catalytic domain of human phenylalanine hydroxylase with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine, and its implications for the mechanism of catalysis and substrate activation (2002), J. Mol. Biol., 320, 1095-1108.

Search for more literature for 1.14.16.1

Cloned(Commentary)

Cloned (Comment)	Organism
expression of double truncated mutant enzyme DELTAN1-102/DELTAC428-452 in Escherichia coli	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal structure of ternary complex of catalytic domain, Fe2+ form, with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P00439	-	-

Purification (Commentary)

Purification (Comment)	Organism
double truncated mutant enzyme DELTAN1-102/DELTAC428-452	Homo sapiens

Reaction

Reaction	Comment	Organism	Reaction ID
L-phenylalanine + a 5,6,7,8-tetrahydropteridine + O2 = L-tyrosine + a 4a-hydroxy-5,6,7,8-tetrahydropteridine	proposed catalytic cycle	Homo sapiens	a

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Release 2023.1 (January 2023)