Crystallization (Comment) | Organism |
---|---|
substrate-free enzyme to 1.8 A resolution, cocrystallization of CYP106A2 with abietic acid reveals bending of the heme cofactor when abietic acid is bound in the active site | Priestia megaterium |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Priestia megaterium | Q06069 | isoform Cyp106A2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
abietic acid + reduced adrenodoxin + O2 | binding of abietic acid results in a type II difference spectrum typical for nitrogenous inhibitors | Priestia megaterium | ? + oxidized adrenodoxin + H2O | - |
? | |
dehydroabietic acid + reduced adrenodoxin + O2 | - |
Priestia megaterium | ? + oxidized adrenodoxin + H2O | - |
? | |
isopimaric acid + reduced adrenodoxin + O2 | - |
Priestia megaterium | ? + oxidized adrenodoxin + H2O | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | presence of dehydroabietic acid does not induce a high-spin shift of the enzyme | Priestia megaterium |