Literature summary for 1.14.15.6 extracted from

Davydov, R.; Strushkevich, N.; Smil, D.; Yantsevich, A.; Gilep, A.; Usanov, S.; Hoffman, B.M.
Evidence that compound I is the active species in both the hydroxylase and lyase steps by which P450scc converts cholesterol to pregnenolone EPR/ENDOR/cryoreduction/annealing Studies (2015), Biochemistry, 54, 7089-7097 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P05108	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(20R,22R)-20,22-dihydroxy-cholesterol + 2 reduced adrenodoxin + O2	-	Homo sapiens	pregnenolone + 4-methylpentanal + 2 oxidized adrenodoxin + 2 H2O	-	?
(22R)-22-hydroxycholesterol + 2 reduced adrenodoxin + O2	-	Homo sapiens	(20R,22R)-20,22-dihydroxycholesterol + 2 oxidized adrenodoxin + H2O	-	?
additional information	compound I, i.e. ferryl porphyrin pi-cation radical, is the active species in each of the three sequential monooxygenation reactions by which P450scc catalytically converts Ch to pregnenolone	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
CYP 11A1	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
heme	compound I, i.e. ferryl porphyrin pi-cation radical, is the active species in each of the three sequential monooxygenation reactions by which P450scc catalytically converts Ch to pregnenolone	Homo sapiens

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Release 2023.1 (January 2023)