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Literature summary for 1.14.15.6 extracted from

  • Pikuleva, I.A.
    Cholesterol-metabolizing cytochromes P450 (2006), Drug Metab. Dispos., 34, 513-520.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information mutation of a cysteine residue in the F-G loop leads to altered membrane interaction and activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial inner membrane membrane topology, overview Homo sapiens 5743
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + reduced ferredoxin + O2 Homo sapiens the catalyzed reaction is not the rate-limiting step in steroidogenesis except in placenta which lacks the steroidogenic acute regulatory protein, overview, enzyme deficiency by mutations leads to severe disorders, overview pregnenolone + 4-methylpentanal + oxidized ferredoxin
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Homo sapiens
-
brain
-
Homo sapiens
-
additional information the enzyme is expressed mainly in steroidogenic tissue Homo sapiens
-
ovary
-
Homo sapiens
-
placenta
-
Homo sapiens
-
testis
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + reduced ferredoxin + O2 the catalyzed reaction is not the rate-limiting step in steroidogenesis except in placenta which lacks the steroidogenic acute regulatory protein, overview, enzyme deficiency by mutations leads to severe disorders, overview Homo sapiens pregnenolone + 4-methylpentanal + oxidized ferredoxin
-
?
cholesterol + reduced ferredoxin + O2 the enzyme is a cytochrome P450 enzyme, the enzyme structure possesses a substrate access channel, which is responsible for regioselectivity of the enzyme together with residue F202 Homo sapiens pregnenolone + 4-methylpentanal + oxidized ferredoxin
-
?

Subunits

Subunits Comment Organism
More the enzyme structure possesses a substrate access channel, the F-G loop is a membrane-interacting area Homo sapiens

Synonyms

Synonyms Comment Organism
CYP11A1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
Ferredoxin
-
Homo sapiens
Iron the enzyme is a cytochrome P450 enzyme Homo sapiens