Protein Variants | Comment | Organism |
---|---|---|
additional information | mutation of a cysteine residue in the F-G loop leads to altered membrane interaction and activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial inner membrane | membrane topology, overview | Homo sapiens | 5743 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + reduced ferredoxin + O2 | Homo sapiens | the catalyzed reaction is not the rate-limiting step in steroidogenesis except in placenta which lacks the steroidogenic acute regulatory protein, overview, enzyme deficiency by mutations leads to severe disorders, overview | pregnenolone + 4-methylpentanal + oxidized ferredoxin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Homo sapiens | - |
brain | - |
Homo sapiens | - |
additional information | the enzyme is expressed mainly in steroidogenic tissue | Homo sapiens | - |
ovary | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + reduced ferredoxin + O2 | the catalyzed reaction is not the rate-limiting step in steroidogenesis except in placenta which lacks the steroidogenic acute regulatory protein, overview, enzyme deficiency by mutations leads to severe disorders, overview | Homo sapiens | pregnenolone + 4-methylpentanal + oxidized ferredoxin | - |
? | |
cholesterol + reduced ferredoxin + O2 | the enzyme is a cytochrome P450 enzyme, the enzyme structure possesses a substrate access channel, which is responsible for regioselectivity of the enzyme together with residue F202 | Homo sapiens | pregnenolone + 4-methylpentanal + oxidized ferredoxin | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the enzyme structure possesses a substrate access channel, the F-G loop is a membrane-interacting area | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
CYP11A1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
Ferredoxin | - |
Homo sapiens | |
Iron | the enzyme is a cytochrome P450 enzyme | Homo sapiens |