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Literature summary for 1.14.15.4 extracted from
- Norharman (beta-carboline) as a potent inhibitory ligand for steroidogenic cytochromes P450 (CYP11 and CYP17) (1993), Eur. J. Pharmacol., 250, R1-3.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no inhibition with Harman, tetrahydronorharman and tetrahydroharman | Rattus norvegicus | |
| norharman | beta-carboline, high affinity type II ligand to both cytochromes, progesterone binding to CYP17 competitively inhibited | Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | CYP17 | Rattus norvegicus | - |
- |
| mitochondrion | CYP11 | Rattus norvegicus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal cortex | - |
Rattus norvegicus | - |
| testis | - |
Rattus norvegicus | - |
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