BRENDA - Enzyme Database
show all sequences of 1.14.15.27

Biosynthesis and regulation of sulfomenaquinone, a metabolite associated with virulence in Mycobacterium tuberculosis

Sogi, K.M.; Holsclaw, C.M.; Fragiadakis, G.K.; Nomura, D.K.; Leary, J.A.; Bertozzi, C.R.; ACS Infect. Dis. 2, 800-806 (2016)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2
Mycobacterium tuberculosis
-
omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
?
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2
Mycobacterium tuberculosis H37Rv
-
omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Mycobacterium tuberculosis
P9WPN7
-
-
Mycobacterium tuberculosis H37Rv
P9WPN7
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2
-
743926
Mycobacterium tuberculosis
omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
?
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2
-
743926
Mycobacterium tuberculosis H37Rv
omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
cyp128
-
Mycobacterium tuberculosis
Rv2268c
-
Mycobacterium tuberculosis
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2
Mycobacterium tuberculosis
-
omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
?
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2
Mycobacterium tuberculosis H37Rv
-
omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2
-
743926
Mycobacterium tuberculosis
omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
?
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2
-
743926
Mycobacterium tuberculosis H37Rv
omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
?
General Information
General Information
Commentary
Organism
physiological function
Cyp128 and sulfotransferase Stf 3 are sufficient for the biosynthesis of sulfomenaquinone from menaquinone in recombinant Mycobacterium smegmatis. In a mouse model of infection the loss of Cyp128 exhibits a hypervirulent phenotype similar to that in previous studies of the Stf 3 mutant
Mycobacterium tuberculosis
General Information (protein specific)
General Information
Commentary
Organism
physiological function
Cyp128 and sulfotransferase Stf 3 are sufficient for the biosynthesis of sulfomenaquinone from menaquinone in recombinant Mycobacterium smegmatis. In a mouse model of infection the loss of Cyp128 exhibits a hypervirulent phenotype similar to that in previous studies of the Stf 3 mutant
Mycobacterium tuberculosis
Other publictions for EC 1.14.15.27
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
743926
Sogi
Biosynthesis and regulation o ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
ACS Infect. Dis.
2
800-806
2016
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6
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2
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2
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2
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1
1
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743921
Holsclaw
Structural characterization o ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
ACS Chem. Biol.
3
619-624
2008
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3
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1
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1
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