Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | phorbol myristate acetate, lipopolysaccharide, and IFNgamma induce enzyme expression in monocytes, regulation, the induction essentially requires the JAK-STAT, NF-kappaB, and p38 MAPK pathways, chromatin remodeling is required for immune-mediated up-regulation of 1alpha-hydroxylase, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | inhibitory effects of the MEK inhibitor PD98059, p38 MAPK inhibitor SB203580, and JNK inhibitor SP600125 on the IFNgamma/PMA-induced or IFNgamma/LPS-induced 1alpha-hydroxylase mRNA expression in THP1 cells, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
25-hydroxyvitamin D + NADPH + O2 | Homo sapiens | substrate activation by the rate-limiting enzyme 1alpha-hydroxylase in cells of the immune system under control of immune stimuli, such as interferon-gamma, in pathological situations, such as sarcoidosis, this can lead to systemic excess of 1,25(OH)2D3 and hypercalcemia | 1alpha,25-dihydroxyvitamin D + NADP+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15528 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | - |
Homo sapiens | - |
monocyte | - |
Homo sapiens | - |
THP-1 cell | monocytic cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
25-hydroxyvitamin D + NADPH + O2 | - |
Homo sapiens | 1alpha,25-dihydroxyvitamin D + NADP+ + H2O | - |
? | |
25-hydroxyvitamin D + NADPH + O2 | substrate activation by the rate-limiting enzyme 1alpha-hydroxylase in cells of the immune system under control of immune stimuli, such as interferon-gamma, in pathological situations, such as sarcoidosis, this can lead to systemic excess of 1,25(OH)2D3 and hypercalcemia | Homo sapiens | 1alpha,25-dihydroxyvitamin D + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
25-hydroxyvitamin D-1alpha-hydroxylase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |