Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | enzyme expression in monocytes is synergistically induced by IFNgamma and CD14/TLR4 ligation and paralleled by 1,25(OH)2D3 production, the induction essentially requires the JAK-STAT, NF-kappaB, and p38 MAPK pathways, expression analysis, overview | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressionin RAW264.7 cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
25-hydroxyvitamin D + NADPH + O2 | Homo sapiens | the enzyme is responsible for final hydroxylation of vitamin D3, in response to IFNgamma and CD14/TLR4 activation | 1alpha,25-dihydroxyvitamin D + NADP+ + H2O | - |
? | |
additional information | Homo sapiens | immune regulation of the enzyme in monocytes, cross-talk between the JAK-STAT, the NFkappaB, and the p38 MAPK pathways is necessary, and direct binding of C/EBPbeta to its recognition sites in the promoter of the 1alpha-hydroxylase gene is a prerequisite, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
monocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
25-hydroxyvitamin D + NADPH + O2 | - |
Homo sapiens | 1alpha,25-dihydroxyvitamin D + NADP+ + H2O | - |
? | |
25-hydroxyvitamin D + NADPH + O2 | the enzyme is responsible for final hydroxylation of vitamin D3, in response to IFNgamma and CD14/TLR4 activation | Homo sapiens | 1alpha,25-dihydroxyvitamin D + NADP+ + H2O | - |
? | |
additional information | immune regulation of the enzyme in monocytes, cross-talk between the JAK-STAT, the NFkappaB, and the p38 MAPK pathways is necessary, and direct binding of C/EBPbeta to its recognition sites in the promoter of the 1alpha-hydroxylase gene is a prerequisite, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
25-hydroxyvitamin-D3-1alpha-hydroxylase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |