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Literature summary for 1.14.15.18 extracted from

  • Ma, J.F.; Nonn, L.; Campbell, M.J.; Hewison, M.; Feldman, D.; Peehl, D.M.
    Mechanisms of decreased Vitamin D 1alpha-hydroxylase activity in prostate cancer cells (2004), Mol. Cell. Endocrinol., 221, 67-74.
    View publication on PubMed
Search for more literature for 1.14.15.18

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
56000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
25-hydroxyvitamin D3 + NADPH + O2 Homo sapiens final step of the activation of vitamin D, involved in tumor suppressing activity due to the tumor growth inhibiting effect of 1alpha,25-dihydroxyvitamin D3 1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
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Source Tissue

Source Tissue Comment Organism Textmining
DU-145 cell prostate cancer cell line, greatly decreased activity of 25-hydroxyvitamin D-1alpha-hydroxylase due to decreased RNA transcription Homo sapiens
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kidney
-
 Homo sapiens
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LNCaP cell prostate cancer cell line, greatly decreased activity of 25-hydroxyvitamin D-1alpha-hydroxylase due to decreased RNA transcription Homo sapiens
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PC-3 cell prostate cancer cell line, greatly decreased activity of 25-hydroxyvitamin D-1alpha-hydroxylase due to decreased RNA transcription Homo sapiens
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prostate tissue obtained from normal prostate, benign prostatic hyperplastia or cancer, primary and cultured prostate cancer cells have greatly decreased activity of 25-hydroxyvitamin D-1alpha-hydroxylase and are therefore resistant to the tumor suppressing activity of circulating 25-hydroxyvitamin D3 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
25-hydroxyvitamin D3 + NADPH + O2
-
 Homo sapiens 1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O
-
 ?
25-hydroxyvitamin D3 + NADPH + O2 final step of the activation of vitamin D, involved in tumor suppressing activity due to the tumor growth inhibiting effect of 1alpha,25-dihydroxyvitamin D3 Homo sapiens 1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
25-hydroxyvitamin D-1alpha-hydroxylase
-
 Homo sapiens