Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.15.18 extracted from

  • Daniel, D.; Middleton, R.; Henry, H.L.; Okamura, W.H.
    Inhibitors of 25-hydroxyvitamin D3 1a-hydroxylase: A-ring oxa analogs of 25-hydroxyvitamin D3 (1996), J. Org. Chem., 61, 5617-5625.
No PubMed abstract available
Search for more literature for 1.14.15.18

Activating Compound

Activating Compound Comment Organism Structure
malate
-
 Gallus gallus

Inhibitors

Inhibitors Comment Organism Structure
25-hydroxy-3-deoxy-2-oxavitamin D3 vitamin D3 analogue, competitive inhibition Gallus gallus
3-deoxy-2-oxa-9(11)-didehydro-25-hydroxyvitamin D3 vitamin D3 analogue, competitive inhibition Gallus gallus
A-homo-3-deoxy-2-oxa-25-hydroxyvitamin D3 vitamin D3 analogue, competitive inhibition Gallus gallus
additional information overview, inhibitory potency of several vitamin D3 analogues Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Gallus gallus 5739
-

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O 25-hydroxyvitamin D3 1alpha-hydroxylase is a cytochrome P-450-dependent mixed-function oxidase Gallus gallus
a

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
calcidiol + NADPH + O2 highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol Gallus gallus calcitriol + NADP+ + H2O calcitriol is identical with 1,25-dihydroxycholecalciferol ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Gallus gallus