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Literature summary for 1.14.15.18 extracted from

  • Grieff, M.; Dusso, A.; Mori, T.; Nishii, Y.; Slatopolsky, E.; Brown, A.J.
    22-Oxacalcitriol suppresses 25-hydroxycholecalciferol-1a-hydroxylase in rat kidney (1992), Biochem. Biophys. Res. Commun., 185, 191-196.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
22-oxacalcitriol vitamin D3 analogue, inhibits in vitro and in vivo Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
25-hydroxycholecalciferol + NADPH + O2 Rattus norvegicus central role in calcium regulation calcitriol + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney renal cortex Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
25-hydroxycholecalciferol + NADPH + O2 central role in calcium regulation Rattus norvegicus calcitriol + NADP+ + H2O
-
 ?
calcidiol + NADPH + O2 highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol Rattus norvegicus calcitriol + NADP+ + H2O calcitriol is identical with 1,25-dihydroxycholecalciferol ?