Literature summary for 1.14.15.18 extracted from

Henry, H.L.; Norman, A.W.
Studies on calciferol metabolism. Regulation of 25-hydroxyvitamin D3-1-hydroxylase in isolated renal mitochondria (1976), Arch. Biochem. Biophys., 172, 582-589.

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Activating Compound

Activating Compound	Comment	Organism	Structure
malate	supports 1alpha-hydroxylation as electron donor	Gallus gallus

Inhibitors

Inhibitors	Comment	Organism	Structure
Ca2+	-	Gallus gallus
ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid	-	Gallus gallus
phosphate	-	Gallus gallus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Gallus gallus	5739	-

Organism

Organism	UniProt	Comment	Textmining
Gallus gallus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	-	Gallus gallus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.0000031	-	-	Gallus gallus
0.0000048	-	with malate as electron source	Gallus gallus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
calcidiol + NADPH + O2	highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol	Gallus gallus	calcitriol + NADP+ + H2O	calcitriol is identical with 1,25-dihydroxycholecalciferol	?

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Gallus gallus

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Release 2023.1 (January 2023)