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Literature summary for 1.14.15.16 extracted from
- 24-Hydroxylase in cancer: impact on vitamin D-based anticancer therapeutics (2013), J. Steroid Biochem. Mol. Biol., 136, 252-257.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | elevated tumor CYP24A1 expression is associated with a poor prognosis | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-(4-hydroxybenzyl)-6-methoxy-3,4-dihydro-2H-naphthalen-1-one | - |
Homo sapiens |  |
| CTA018 | - |
Homo sapiens | |
| CTA091 | - |
Homo sapiens | |
| ketoconazole | - |
Homo sapiens | |
| liarozole | - |
Homo sapiens | |
| VID400 | i.e. (R)-N-(2-(1H-imidazol-1-yl)-2-phenylethyl)-4-chlorobiphenyl-4-carboxamide, exhibits strong and selective CYP24A1 inhibitory activity | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2 | Homo sapiens | - |
1alpha,24,25-trihydroxyvitamin D3 + NADP+ + H2O | - |
? | |
| 25-hydroxyvitamin D3 + NADPH + H+ + O2 | Homo sapiens | - |
24,25-dihydroxyvitamin D3 + NADP+ + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | highest activity in kidney | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2 | - |
Homo sapiens | 1alpha,24,25-trihydroxyvitamin D3 + NADP+ + H2O | - |
? | |
| 25-hydroxyvitamin D3 + NADPH + H+ + O2 | - |
Homo sapiens | 24,25-dihydroxyvitamin D3 + NADP+ + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP24A1 | - |
Homo sapiens |
| vitamin D 24-hydroxylase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000015 | - |
pH and temperature not specified in the publication | Homo sapiens | VID400 | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | enzyme expression is upregulated in cancer cells | up |
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