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Literature summary for 1.14.15.16 extracted from

  • Prosser, D.E.; Jones, G.
    Enzymes involved in the activation and inactivation of vitamin D (2004), Trends Biochem. Sci., 29, 664-673.
    View publication on PubMed
Search for more literature for 1.14.15.16

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney the enzyme is absent from the liver and osteoclasts Mus musculus
-
kidney the enzyme is absent from the liver and osteoclasts Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1alpha,23,25-trihydroxyvitamin D3 + NADPH + H+ + O2
-
 Mus musculus 1alpha,25-dihydroxyvitamin D3-26,23-lactone + NADP+ + H2O
-
 ?
1alpha,23,25-trihydroxyvitamin D3 + NADPH + H+ + O2
-
 Homo sapiens 1alpha,25-dihydroxyvitamin D3-26,23-lactone + NADP+ + H2O
-
 ?
1alpha,24R,25-trihydroxyvitamin D3 + NADPH + O2
-
 Mus musculus calcitroic acid + NADP+ + ?
-
 ?
1alpha,24R,25-trihydroxyvitamin D3 + NADPH + O2
-
 Homo sapiens calcitroic acid + NADP+ + ?
-
 ?
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2
-
 Mus musculus 1alpha,23,25-trihydroxyvitamin D3 + NADP+ + H2O
-
 ?
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2
-
 Homo sapiens 1alpha,23,25-trihydroxyvitamin D3 + NADP+ + H2O
-
 ?
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2
-
 Mus musculus 1alpha,24R,25-trihydroxyvitamin D3 + NADP+ + H2O
-
 ?
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2
-
 Homo sapiens 1alpha,24R,25-trihydroxyvitamin D3 + NADP+ + H2O
-
 ?
25-hydroxyvitamin D3 + NADPH + H+ + O2
-
 Mus musculus 24R,25-dihydroxyvitamin D3 + NADP+ + H2O
-
 ?
25-hydroxyvitamin D3 + NADPH + H+ + O2
-
 Homo sapiens 24R,25-dihydroxyvitamin D3 + NADP+ + H2O
-
 ?
calcidiol + NADPH + H+ + O2
-
 Mus musculus secalciferol + NADP+ + H2O
-
 ?
calcidiol + NADPH + H+ + O2
-
 Homo sapiens secalciferol + NADP+ + H2O
-
 ?
calcitriol + NADPH + H+ + O2
-
 Mus musculus calcitetrol + NADP+ + H2O
-
 ?
calcitriol + NADPH + H+ + O2
-
 Homo sapiens calcitetrol + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
25-OH-D3-24-hydroxylase
-
 Mus musculus
25-OH-D3-24-hydroxylase
-
 Homo sapiens
CYP24A1
-
 Mus musculus
CYP24A1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Mus musculus
NADPH
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus CYP24A1 is transcriptionally induced in vitamin D target cells by the action of 1alpha,25-dihydroxyvitamin D3 up
Homo sapiens CYP24A1 is transcriptionally induced in vitamin D target cells by the action of 1alpha,25-dihydroxyvitamin D3 up

General Information

General Information Comment Organism
malfunction the Cyp24a1 knockout mouse is consistent with a catabolic role for CYP24A1, because it shows poor viability, 50% of homozygous mice die before weaning, showing hypercalcemia and signs of renal calcification. Isolated cultured keratinocytes from Cyp24a1-deficient mice fail to synthesize calcitroic acid Mus musculus
physiological function CYP24A1 has a crucial role in vitamin D inactivation in vivo Mus musculus
physiological function CYP24A1 has a crucial role in vitamin D inactivation in vivo Homo sapiens