Literature summary for 1.14.15.15 extracted from

Charvet, C.; Liao, W.L.; Heo, G.Y.; Laird, J.; Salomon, R.G.; Turko, I.V.; Pikuleva, I.A.
Isolevuglandins and mitochondrial enzymes in the retina: mass spectrometry detection of post-translational modification of sterol-metabolizing CYP27A1 (2011), J. Biol. Chem., 286, 20413-20422.

Search for more literature for 1.14.15.15

Application

Application	Comment	Organism
medicine	treatment of enzyme with iso[4]levuglandin E2 in vitro diminishes enzyme activity. Lys residues Lys134, Lys358, and Lys476, readily interact iso[4]levuglandin E2 in vitro, and modified CYP27A1 is present in the retina. The post-translational modifications may exemplify a general mechanism whereby oxidative stress and inflammation deleteriously affect protein function, contributing, for example, to cholesterol-rich lesions associated with age-related macular degeneration and cardiovascular disease	Bos taurus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Bos taurus	5739	-

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
side-chain modification	treatment of enzyme with iso[4]levuglandin E2 in vitro diminishes enzyme activity. Lys residues Lys134, Lys358, and Lys476, readily interact iso[4]levuglandin E2 in vitro, and modified CYP27A1 is present in the retina	Bos taurus

Source Tissue

Source Tissue	Comment	Organism	Textmining
retina	-	Bos taurus	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)