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Literature summary for 1.14.14.B11 extracted from

  • Cai, B.; Bush, L.
    Variable nornicotine enantiomeric composition caused by nicotine demethylase CYP82E4 in tobacco leaf (2012), J. Agric. Food Chem., 60, 11586-11591.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-nicotine + [reduced NADPH-hemoprotein reductase] + O2 Nicotiana tabacum CYP82E4 selectively demethylates (S)-nicotine (S)-nornicotine + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
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Organism

Organism UniProt Comment Textmining
Nicotiana tabacum
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cultivar TN 90LC
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Source Tissue

Source Tissue Comment Organism Textmining
leaf
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Nicotiana tabacum
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-nicotine + [reduced NADPH-hemoprotein reductase] + O2 CYP82E4 selectively demethylates (S)-nicotine Nicotiana tabacum (S)-nornicotine + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
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?

Synonyms

Synonyms Comment Organism
CYP82E4
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Nicotiana tabacum

Cofactor

Cofactor Comment Organism Structure
NADPH
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Nicotiana tabacum