Activating Compound | Comment | Organism | Structure |
---|---|---|---|
lipopolysaccharide | upregulates expression and activity of LTB4OH in ex-smokers in a dose-dependent manner, but not in smokers. In vitro smoke exposure of ex-smokers' bronchoalveolar lavage cells abrogates the lipopolysaccharide-induced up-regulation of LTB4OH mRNA expression, thus tobacco smoke alters bronchoalveolar lavage cell LTB4OH mRNA expression in response to lipopolysaccharide exposure | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
17-octadecynoic acid | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bronchoalveolar lavage | ex-smokers express significantly higher LTB4OH mRNA levels than smokers | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LTB4 omega-hydroxylase | - |
Homo sapiens |
LTB4OH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | by regulating the balance of leukotriene B4 in the lung, LTB4OH may function as a suppressor of lung carcinogenesis | Homo sapiens |