Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | CYP4F18 expression is induced in bone marrow-derived dendritic cells by bacterial lipopolysaccharide, a ligand for TLR4, and by poly(I-C), a ligand for TLR3 | Mus musculus |
Cloned (Comment) | Organism |
---|---|
gene Cyp4f18, expression analysis of CYP4F18 in different cell types, recombinant expression of the enzyme in Spodoptera frugiperda Sf9 cell microsomes via baculovirus transfection system | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | in vivo inhibition of CYP4F18 results in a marked increase in calcium flux and a 220% increase in the chemotactic response of mouse PMN to LTB4 | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + [reduced NADPH-hemoprotein reductase] + O2 | Mus musculus | LTB4 inactivation, in vivo inhibition of CYP4F18 results in a marked increase in calcium flux and a 220% increases in the chemotactic response of mouse polymorphonuclear leukocytes to LTB4 | (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
additional information | Mus musculus | CYP4F18 is a critical protein in the regulation of LTB4 metabolism, the enzyme is active in down-regulation of responses to leukotriene B4, i.e. LTB4, leukotriene B4 is a potent chemoattractant for polymorphonuclear leukocytes and other cells, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
gene Cyp4f18 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow | - |
Mus musculus | - |
dendritic cell | bone marrow-derived, in vitro differentiation | Mus musculus | - |
leukocyte | polymorphonuclear | Mus musculus | - |
additional information | tissue-specific expression, expression analysis of CYP4F18 in different cell types, tissue distribution, overview | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + [reduced NADPH-hemoprotein reductase] + O2 | - |
Mus musculus | (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + [reduced NADPH-hemoprotein reductase] + O2 | LTB4 inactivation, in vivo inhibition of CYP4F18 results in a marked increase in calcium flux and a 220% increases in the chemotactic response of mouse polymorphonuclear leukocytes to LTB4 | Mus musculus | (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
additional information | CYP4F18 is a critical protein in the regulation of LTB4 metabolism, the enzyme is active in down-regulation of responses to leukotriene B4, i.e. LTB4, leukotriene B4 is a potent chemoattractant for polymorphonuclear leukocytes and other cells, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP4F18 | - |
Mus musculus |
cytochrome P-450 4F18 | - |
Mus musculus |
leukotriene B4 omega-1/omega-2 hydroxylase | - |
Mus musculus |