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Literature summary for 1.14.14.83 extracted from

  • Oudin, A.; Courtois, M.; Rideau, M.; Clastre, M.
    The iridoid pathway in Catharanthus roseus alkaloid biosynthesis (2007), Phytochem. Rev., 6, 259-276.
No PubMed abstract available
Search for more literature for 1.14.14.83

Cloned(Commentary)

Cloned (Comment) Organism
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 Catharanthus roseus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
geraniol + [reduced NADPH-hemoprotein reductase] + O2 Catharanthus roseus
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 10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
nerol + [reduced NADPH-hemoprotein reductase] + O2 Catharanthus roseus cis-isomer of geraniol 10-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
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 ?

Organism

Organism UniProt Comment Textmining
Catharanthus roseus
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 two constituents of geraniol 10-hydroxylase, gene CYP76B6
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geraniol + [reduced NADPH-hemoprotein reductase] + O2
-
 Catharanthus roseus 10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
nerol + [reduced NADPH-hemoprotein reductase] + O2 cis-isomer of geraniol Catharanthus roseus 10-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP76B6 protein
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 Catharanthus roseus
G10H
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 Catharanthus roseus

Expression

Organism Comment Expression
Catharanthus roseus G10H is repressed by ketonazole down
Catharanthus roseus various hormones and elicitors upregulate G10H and the monoterpene alkaloid biosynthesis pathways. G10H activity is induced by phenobarbital up

General Information

General Information Comment Organism
metabolism the enzyme is one of the key enzymes of the biosynthesis of monoterpene indole alkaloids that originate from the coupling of the indole and the iridoid pathways. Overview of metabolic pathways leading to the biosynthesis of monoterpene indole alkaloids and their metabolic regulation Catharanthus roseus
additional information geraniol 10-hydroxylase is a cytochrome P450 monooxygenase. It consists of a reductase and a monooxygenase. The cytochrome P450 reductase, EC 1.6.2.4, is a membrane-bound flavoprotein, which transfers electrons from NADPH to the cytochrome P450 monooxygenase, CPR requires the cofactors FMN, FAD and NADPH Catharanthus roseus