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Literature summary for 1.14.14.78 extracted from

  • Edson, K.Z.; Prasad, B.; Unadkat, J.D.; Suhara, Y.; Okano, T.; Guengerich, F.P.; Rettie, A.E.
    Cytochrome P450-dependent catabolism of vitamin K: omega-hydroxylation catalyzed by human CYP4F2 and CYP4F11 (2013), Biochemistry, 52, 8276-8285.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
menaquinone-4 + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 omega-hydroxymenaquinone-4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
phylloquinone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 omega-hydroxyphylloquinone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
menaquinone-4 + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens omega-hydroxymenaquinone-4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
phylloquinone + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens omega-hydroxyphylloquinone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP4F11
-
 Homo sapiens
CYP4F2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens