Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.73 extracted from

  • Moroni, P.; Buronfosse, T.; Longin-Sauvageon, C.; Delatour, P.; Benoit, E.
    Chiral sulfoxidation of albendazole by the flavin adenine dinucleotide-containing and cytochrome P450-dependent monooxygenases from rat liver microsomes (1995), Drug Metab. Dispos., 23, 160-165 .
    View publication on PubMed
Search for more literature for 1.14.14.73

Inhibitors

Inhibitors Comment Organism Structure
clotrimazole
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
albendazole + [reduced NADPH-hemoprotein reductase] + O2
-
 Rattus norvegicus albendazole S-oxide + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
cytochrome P450
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function two main enzymatic systems, cytochrome P450s and flavin-containing monooxygenase, are responsible for the sulfoxidation of albendazole. P450 inhibitors inhibit the production of (-)-albendazole S-oxide more than the production of (+)-albendazole S-oxide Rattus norvegicus