Literature summary for 1.14.14.67 extracted from

Guo, J.; Ma, X.; Cai, Y.; Ma, Y.; Zhan, Z.; Zhou, Y.J.; Liu, W.; Guan, M.; Yang, J.; Cui, G.; Kang, L.; Yang, L.; Shen, Y.; Tang, J.; Lin, H.; Ma, X.; Jin, B.; Liu, Z.; Peters, R.J.; Zhao, Z.K.; Huang, L.
Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones (2016), New Phytol., 210, 525-534 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Saccharomyces cerevisiae	Salvia miltiorrhiza

Crystallization (Commentary)

Crystallization (Comment)	Organism
homology modeling of structure	Salvia miltiorrhiza

Organism

Organism	UniProt	Comment	Textmining
Salvia miltiorrhiza	A0A125QZE2	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hairy root	-	Salvia miltiorrhiza	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
11-hydroxyferruginol + [reduced NADPH-hemoprotein reductase] + O2	-	Salvia miltiorrhiza	11,20-dihydroxyferruginol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?
11-hydroxysugiol + [reduced NADPH-hemoprotein reductase] + O2	-	Salvia miltiorrhiza	11,20-dihydroxysugiol + [oxidized NADPH-hemoprotein reductase] + H2O	-	?
additional information	enzyme hydroxylates 11-hydroxyferruginol and 11-hydroxysugiol at C-20 to give 11,20-dihydroxyferruginal and 11,20-dihydroxysugiol	Salvia miltiorrhiza	?	-	?

Synonyms

Synonyms	Comment	Organism
CYP76AK1	-	Salvia miltiorrhiza

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Release 2023.1 (January 2023)