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Literature summary for 1.14.14.57 extracted from

  • Araya, Z.; Wikvall, K.
    6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes (1999), Biochim. Biophys. Acta, 1438, 47-54 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in insect cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibitory or very little effect: alpha-naphthoflavone, sulfaphenazole and tranylcypromine Homo sapiens
troleandomycin 0.01 mM, almost complete inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.09
-
taurochenodeoxycholate pH 7.4, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lithocholate + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens hyodeoxycholate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
additional information isofornm CYP3A4 is the only enzyme tested which is active towards bile acids taurochenodeoxycholate and lithocholate. The enzyme catalyzes an efficient 6alpha-hydroxylation of both taurochenodeoxycholic acid and lithocholic acid Homo sapiens ?
-
?
taurochenodeoxycholate + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens taurohyocholate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

Synonyms Comment Organism
CYP3A4
-
Homo sapiens

General Information

General Information Comment Organism
physiological function a strong correlation exists between 6alpha-hydroxylation of taurochenodeoxycholic acid, CYP3A levels and testosterone 6beta-hydroxylation. There is also a strong correlation between 6alpha-hydroxylation of lithocholic acid, CYP3A levels and testosterone 6beta-hydroxylation Homo sapiens