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Literature summary for 1.14.14.55 extracted from

  • Wanwimolruk, S.; Wong, K.; Wanwimolruk, P.
    Variable inhibitory effect of different brands of commercial herbal supplements on human cytochrome P-450 CYP3A4 (2009), Drug Metabol. Drug Interact., 24, 17-35.
    View publication on PubMed
Search for more literature for 1.14.14.55

Activating Compound

Activating Compound Comment Organism Structure
grape seed extract some brands cause minor activation of CYP3A4 Homo sapiens

Application

Application Comment Organism
medicine green tea extract use may cause significant interactions with drugs metabolized by CYP3A4. Effect on CYP3A4 varies among different brands of green tea extract, possibly due to variations in their content of the herbal product's active ingredients Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
grape seed extract inhibition ranges from 6.4% to 26.8% dependent on the product Homo sapiens
green tea extract most pronounced inhibition of CYP3A4, which ranges from 5.6% to 89.9% dependent on the product Homo sapiens
additional information ginseng products have little to no effect on the activity of CYP3A4 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P08684
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
quinine + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP3A4
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens