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Literature summary for 1.14.14.54 extracted from
- Disruption of phacA, an Aspergillus nidulans gene encoding a novel cytochrome P450 monooxygenase catalyzing phenylacetate 2-hydroxylation, results in penicillin overproduction (1999), J. Biol. Chem., 274, 14545-14550 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phenylacetate + [reduced NADPH-hemoprotein reductase] + O2 | Aspergillus nidulans | - |
(2-hydroxyphenyl)acetate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aspergillus nidulans | Q9Y7G5 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mycelium | - |
Aspergillus nidulans | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phenylacetate + [reduced NADPH-hemoprotein reductase] + O2 | - |
Aspergillus nidulans | (2-hydroxyphenyl)acetate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PhAc 2-hydroxylase | - |
Aspergillus nidulans |
| phacA | - |
Aspergillus nidulans |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Aspergillus nidulans | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Aspergillus nidulans | gene transcription is strongly induced by phenylacetate | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | enzyme gene disruption results in increased penicillin production | Aspergillus nidulans |
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