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Literature summary for 1.14.14.42 extracted from

  • Hansen, C.H.; Wittstock, U.; Olsen, C.E.; Hick, A.J.; Pickett, J.A.; Halkier, B.A.
    Cytochrome p450 CYP79F1 from Arabidopsis catalyzes the conversion of dihomomethionine and trihomomethionine to the corresponding aldoximes in the biosynthesis of aliphatic glucosinolates (2001), J. Biol. Chem., 276, 11078-11085.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-dihomomethionine + 2 O2 + 2 [reduced NADPH-hemoprotein reductase] Arabidopsis thaliana
-
omega-(methylthio)-(E)-pentanaldehyde oxime + CO2 + 3 H2O + 2 [oxidized NADPH-hemoprotein reductase] overall reaction, product is the precursor of the major glucosinolates in leaves of Arabidopsis thaliana ?
L-trihomomethionine + 2 O2 + 2 [reduced NADPH-hemoprotein reductase] Arabidopsis thaliana
-
omega-(methylthio)-(E)-hexanaldehyde oxime + CO2 + 3 H2O + 2 [oxidized NADPH-hemoprotein reductase] overall reaction ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q949U1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-dihomomethionine + 2 O2 + 2 [reduced NADPH-hemoprotein reductase]
-
Arabidopsis thaliana omega-(methylthio)-(E)-pentanaldehyde oxime + CO2 + 3 H2O + 2 [oxidized NADPH-hemoprotein reductase] overall reaction, product is the precursor of the major glucosinolates in leaves of Arabidopsis thaliana ?
L-trihomomethionine + 2 O2 + 2 [reduced NADPH-hemoprotein reductase]
-
Arabidopsis thaliana omega-(methylthio)-(E)-hexanaldehyde oxime + CO2 + 3 H2O + 2 [oxidized NADPH-hemoprotein reductase] overall reaction ?

Synonyms

Synonyms Comment Organism
CYP79F1
-
Arabidopsis thaliana
dihomomethionine N-hydroxylase
-
Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
cytochrome P450
-
Arabidopsis thaliana

General Information

General Information Comment Organism
physiological function transgenic Arabidopsis thaliana with cosuppression of CYP79F1 have a reduced content of aliphatic glucosinolates and a highly increased level of dihomomethionine and trihomomethionine. The transgenic plants have a morphological phenotype showing loss of apical dominance and formation of multiple axillary shoots Arabidopsis thaliana