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Literature summary for 1.14.14.32 extracted from

  • Huang, X.; Jin, J.; Shen, S.; Xia, Y.; Xu, P.; Zou, X.; Wang, H.; Yi, L.; Wang, Y.; Gao, Q.
    Modulation of expression of 17-Hydroxylase/17,20 lyase (CYP17) and P450 aromatase (CYP19) by inhibition of MEK1 in a human ovarian granulosa-like tumor cell line (2016), Gynecol. Endocrinol., 32, 201-205.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
PD98059 inhibitor of the MEK/ERK pathway. Treatment of cells with PD98059 (10 mM) at 24 and 48 h results in significant increases in the protein levels of CYP17. Production of androstenedione and estradiol significantly increases after treatment with PD98059 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus perinucleus Homo sapiens 5634
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Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
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Source Tissue

Source Tissue Comment Organism Textmining
granulosa cell
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 Homo sapiens
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ovary cancer cell line ovarian granulosa-like tumor cell line, most of the cells are strongly positive for CYP17 and CYP19, especially in the perinuclear region Homo sapiens
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Synonyms

Synonyms Comment Organism
CYP17
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 Homo sapiens

General Information

General Information Comment Organism
physiological function the MEK/ERK pathway functions to inhibit the production of CYP17, while enhance the production of CYP19 in granulosa cells, probably involving a mechanism depending on c-fos, a downstream target of mitogen and extracellular signal-regulated kinases (MEK/ERK) signaling Homo sapiens