Literature summary for 1.14.14.32 extracted from

Khatri, Y.; Gregory, M.C.; Grinkova, Y.V.; Denisov, I.G.; Sligar, S.G.
Active site proton delivery and the lyase activity of human CYP17A1 (2014), Biochem. Biophys. Res. Commun., 443, 179-184.

Search for more literature for 1.14.14.32

Protein Variants

Protein Variants	Comment	Organism
T306A	mutation in the conserved acid/alcohol pair thought to be essential for the efficient delivery of protons. Mutant protein co-incorporated in nanodiscs with its redox partner cytochrome P450 oxidoreductase, couples NADPH only by 0.9% and 0.7% compared to the wild type (97% and 22%) during the conversion of pregnenolone and progesterone, respectively. Hydroxylase activity is drastically diminished in the mutant, while catalysis of carbon-carbon bond scission is largely unimpeded	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
CYP17A1	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)