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Literature summary for 1.14.14.32 extracted from
- At the crossroads of steroid hormone biosynthesis: the role, substrate specificity and evolutionary development of CYP17 (2011), Biochim. Biophys. Acta, 1814, 200-209.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cytochrome b5 | plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17 | Cavia porcellus | |
| cytochrome b5 | plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17 | Mus musculus | |
| cytochrome b5 | plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17 | Rattus norvegicus | |
| cytochrome b5 | plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17 | Sus scrofa | |
| cytochrome b5 | plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17 | Felis catus | |
| cytochrome b5 | plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17 | Equus caballus | |
| cytochrome b5 | plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17 | Papio sp. | |
| cytochrome b5 | plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17 | Pan troglodytes | |
| cytochrome b5 | plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17. Rat cytochrome b5 stimulates the 17,20-lyase activity of bovine CYP17A1 by a factor of 4-5 | Bos taurus | |
| cytochrome b5 | plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17. Rat cytochrome b5 stimulates the 17,20-lyase activity of bovine CYP17A1 by a factor of 4-5 | Ovis aries | |
| cytochrome b5 | plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17. Rat cytochrome b5 stimulates the 17,20-lyase activity of bovine CYP17A1 by a factor of 4-5 | Capra hircus | |
| cytochrome b5 | plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17. Rat cytochrome b5 stimulates the 17,20-lyase activity of bovine CYP17A1 by a factor of 4-5 | Bison bison | |
| cytochrome b5 | plays an important role in regulating the 17,20-lyase reaction catalyzed by CYP17. Rat cytochrome b5 stimulates the 17,20-lyase activity of human CYP17A1 by a factor of 5. The H67A mutant of cytochrome b5 and Zn-substituted b5 are both unable to bind heme and therefore fail to stimulate the catalytic activity of CYP17 | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene CYP17A1, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, expression of wild-type and mutant enzymes in COS-1 cells | Homo sapiens |
| sequence comparisons and phylogenetic analysis | Cavia porcellus |
| sequence comparisons and phylogenetic analysis | Mus musculus |
| sequence comparisons and phylogenetic analysis | Rattus norvegicus |
| sequence comparisons and phylogenetic analysis | Sus scrofa |
| sequence comparisons and phylogenetic analysis | Bos taurus |
| sequence comparisons and phylogenetic analysis | Ovis aries |
| sequence comparisons and phylogenetic analysis | Felis catus |
| sequence comparisons and phylogenetic analysis | Capra hircus |
| sequence comparisons and phylogenetic analysis | Equus caballus |
| sequence comparisons and phylogenetic analysis | Bison bison |
| sequence comparisons and phylogenetic analysis | Papio sp. |
| sequence comparisons and phylogenetic analysis | Pan troglodytes |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D298V | mutant without heme-binding properties | Homo sapiens |
| G111D | mutant without heme-binding properties | Homo sapiens |
| G301I | mutant without heme-binding properties | Homo sapiens |
| G90D | the mutation results in loss of the 17alpha-hydroxylase and 17,20-lyase activities | Homo sapiens |
| additional information | mutations resulting in only the 17,20-lyase deficiency are located either in the putative substrate-binding region of CYP17A1 or in the region responsible for interaction with cytochrome b5 | Homo sapiens |
| additional information | several patients with 17,20-lyase deficiency carry the substitutions Q461stop and R496C. Mutant Q461stop is not active, whereas mutant R496C has low 17alpha-hydroxylase and 17,20-lyase activities | Homo sapiens |
| P342T | the mutant shows 20% of wild type activity | Homo sapiens |
| Q461stop | naturally occuring mutation, inactive mutant | Homo sapiens |
| R347H | naturally occuring mutation, results in loss of the ability of CYP17A1 to catalyze 17,20-lyase reactions, the mutant CYP17A1 loses the ability to interact with cytochrome b5 in recombinant COS-1 cells. Molecular modeling experiments indicate that substitution R347H neutralizes surface positive charges in the region responsible for redox-partner binding | Homo sapiens |
| R347H | the mutation results in loss of the ability of CYP17A1 to catalyze 17,20-lyase reactions | Homo sapiens |
| R358Q | naturally occuring mutation, results in loss of the ability of CYP17A1 to catalyze 17,20-lyase reactions, the mutant CYP17A1 loses the ability to interact with cytochrome b5 in recombinant COS-1 cells. Molecular modeling experiments indicate that substitution R358Q neutralizes surface positive charges in the region responsible for redox-partner binding | Homo sapiens |
| R358Q | the mutation results in loss of the ability of CYP17A1 to catalyze 17,20-lyase reactions | Homo sapiens |
| R449A | naturally occuring mutation, results in loss of the ability of CYP17A1 to catalyze 17,20-lyase reactions | Homo sapiens |
| R449A | the mutation causes loss of 17,20-lyase activity | Homo sapiens |
| R496C | naturally occuring mutation, the mutant has low 17alpha-hydroxylase and 17,20-lyase activities | Homo sapiens |
| R96W | the mutation results in loss of the 17alpha-hydroxylase and 17,20-lyase activities | Homo sapiens |
| S106P | the mutation results in loss of the 17alpha-hydroxylase and 17,20-lyase activities | Homo sapiens |
| T64S | the mutant shows 15% of wild type activity | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| abiraterone acetate | - |
Homo sapiens |  |
| bitertanol | - |
Homo sapiens | |
| fluconazole | - |
Homo sapiens | |
| flusilazole | - |
Homo sapiens | |
| ketoconazole | - |
Homo sapiens | |
| additional information | itraconazole has no effect on human CYP17A1 | Homo sapiens | |
| Propiconazole | - |
Homo sapiens | |
| tebuconazole | highest affinity for human CYP17A1 | Homo sapiens | |
| triadimenol | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum membrane | - |
Cavia porcellus | 5789 | - |
| endoplasmic reticulum membrane | - |
Mus musculus | 5789 | - |
| endoplasmic reticulum membrane | - |
Rattus norvegicus | 5789 | - |
| endoplasmic reticulum membrane | - |
Sus scrofa | 5789 | - |
| endoplasmic reticulum membrane | - |
Bos taurus | 5789 | - |
| endoplasmic reticulum membrane | - |
Ovis aries | 5789 | - |
| endoplasmic reticulum membrane | - |
Felis catus | 5789 | - |
| endoplasmic reticulum membrane | - |
Capra hircus | 5789 | - |
| endoplasmic reticulum membrane | - |
Equus caballus | 5789 | - |
| endoplasmic reticulum membrane | - |
Bison bison | 5789 | - |
| endoplasmic reticulum membrane | - |
Papio sp. | 5789 | - |
| endoplasmic reticulum membrane | - |
Pan troglodytes | 5789 | - |
| endoplasmic reticulum membrane | - |
Homo sapiens | 5789 | - |
| microsome | - |
Cavia porcellus | - |
- |
| microsome | - |
Mus musculus | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
| microsome | - |
Sus scrofa | - |
- |
| microsome | - |
Bos taurus | - |
- |
| microsome | - |
Ovis aries | - |
- |
| microsome | - |
Felis catus | - |
- |
| microsome | - |
Capra hircus | - |
- |
| microsome | - |
Equus caballus | - |
- |
| microsome | - |
Bison bison | - |
- |
| microsome | - |
Papio sp. | - |
- |
| microsome | - |
Pan troglodytes | - |
- |
| microsome | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 17alpha-hydroxypregnenolone + AH2 + O2 | Cavia porcellus | - |
dehydroepiandrosterone + acetate + A + H2O | - |
? | |
| 17alpha-hydroxypregnenolone + AH2 + O2 | Mus musculus | - |
dehydroepiandrosterone + acetate + A + H2O | - |
? | |
| 17alpha-hydroxypregnenolone + AH2 + O2 | Rattus norvegicus | - |
dehydroepiandrosterone + acetate + A + H2O | - |
? | |
| 17alpha-hydroxypregnenolone + AH2 + O2 | Felis catus | - |
dehydroepiandrosterone + acetate + A + H2O | - |
? | |
| 17alpha-hydroxypregnenolone + AH2 + O2 | Bison bison | - |
dehydroepiandrosterone + acetate + A + H2O | - |
? | |
| 17alpha-hydroxypregnenolone + AH2 + O2 | Papio sp. | - |
dehydroepiandrosterone + acetate + A + H2O | - |
? | |
| 17alpha-hydroxypregnenolone + AH2 + O2 | Pan troglodytes | - |
dehydroepiandrosterone + acetate + A + H2O | - |
? | |
| 7-dehydro-pregnenolone + AH2 + O2 | Homo sapiens | - |
7-dehydro-17alpha-hydroxy-pregnenolone + A + H2O | - |
? | |
| 7-dehydro-pregnenolone + AH2 + O2 | Bos taurus | - |
7-dehydro-17alpha-hydroxypregnenolone + A + H2O | - |
? | |
| 7-dehydro-pregnenolone + AH2 + O2 | Ovis aries | - |
7-dehydro-17alpha-hydroxypregnenolone + A + H2O | - |
? | |
| 7-dehydro-pregnenolone + AH2 + O2 | Capra hircus | - |
7-dehydro-17alpha-hydroxypregnenolone + A + H2O | - |
? | |
| additional information | Mus musculus | substrate specificity, comparison of different species, overview | ? | - |
? | |
| additional information | Papio sp. | the baboon enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview | ? | - |
? | |
| additional information | Bison bison | the bison enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview | ? | - |
? | |
| additional information | Bos taurus | the bovine enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview | ? | - |
? | |
| additional information | Felis catus | the cat enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview | ? | - |
? | |
| additional information | Pan troglodytes | the chimp enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview | ? | - |
? | |
| additional information | Capra hircus | the goat enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview | ? | - |
? | |
| additional information | Cavia porcellus | the guinea pig enzyme belongs to the DELTA4-type CYP17, which has no, or very low, 17,20-lyase activity with 17alpha-hydroxy-pregnenolone with the formation of dehydroepiandrosterone, substrate specificity, comparison of different species, overview | ? | - |
? | |
| additional information | Equus caballus | the horse enzyme belongs to the DELTA4,5-type of CYP17, which catalyses the 17alpha-hydroxylation of progesterone and pregnenolone and the 17,20-lyase reaction of 17alpha-hydroxy-progesterone and 17alpha-hydroxy-pregnenolone, substrate specificity, comparison of different species, overview | ? | - |
? | |
| additional information | Homo sapiens | the human enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview | ? | - |
? | |
| additional information | Sus scrofa | the pig enzyme belongs to the DELTA4,5-type of CYP17, which catalyses the 17alpha-hydroxylation of progesterone and pregnenolone and the 17,20-lyase reaction of 17alpha-hydroxy-progesterone and 17alpha-hydroxy-pregnenolone, substrate specificity, comparison of different species, overview | ? | - |
? | |
| additional information | Rattus norvegicus | the rat enzyme belongs to the DELTA4,5-type of CYP17, which catalyses the 17alpha-hydroxylation of progesterone and pregnenolone and the 17,20-lyase reaction of 17alpha-hydroxy-progesterone and 17alpha-hydroxy-pregnenolone, substrate specificity, comparison of different species, overview | ? | - |
? | |
| additional information | Ovis aries | the sheep enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview | ? | - |
? | |
| progesterone + AH2 + O2 | Cavia porcellus | - |
17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | Mus musculus | - |
17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | Rattus norvegicus | - |
17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | Sus scrofa | - |
17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | Bos taurus | - |
17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | Ovis aries | - |
17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | Felis catus | - |
17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | Capra hircus | - |
17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | Equus caballus | - |
17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | Bison bison | - |
17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | Papio sp. | - |
17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | Pan troglodytes | - |
17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | Homo sapiens | - |
17alpha-hydroxyprogesterone + A + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bison bison | - |
- |
- |
| Bos taurus | - |
- |
- |
| Capra hircus | - |
- |
- |
| Cavia porcellus | - |
- |
- |
| Equus caballus | - |
- |
- |
| Felis catus | - |
- |
- |
| Homo sapiens | P05093 | - |
- |
| Homo sapiens | P05093 | CYP17A1; CYP17A1 | - |
| Mus musculus | - |
- |
- |
| Ovis aries | - |
- |
- |
| Pan troglodytes | - |
- |
- |
| Papio sp. | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | phosphorylation of the CYP17 protein affects its stability and activity | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Homo sapiens | - |
| adrenal gland | highest expression | Homo sapiens | - |
| additional information | the tissue-specific expression pattern of the CYP17 gene differs among species | Cavia porcellus | - |
| additional information | the tissue-specific expression pattern of the CYP17 gene differs among species | Mus musculus | - |
| additional information | the tissue-specific expression pattern of the CYP17 gene differs among species | Rattus norvegicus | - |
| additional information | the tissue-specific expression pattern of the CYP17 gene differs among species | Sus scrofa | - |
| additional information | the tissue-specific expression pattern of the CYP17 gene differs among species | Bos taurus | - |
| additional information | the tissue-specific expression pattern of the CYP17 gene differs among species | Ovis aries | - |
| additional information | the tissue-specific expression pattern of the CYP17 gene differs among species | Felis catus | - |
| additional information | the tissue-specific expression pattern of the CYP17 gene differs among species | Capra hircus | - |
| additional information | the tissue-specific expression pattern of the CYP17 gene differs among species | Equus caballus | - |
| additional information | the tissue-specific expression pattern of the CYP17 gene differs among species | Bison bison | - |
| additional information | the tissue-specific expression pattern of the CYP17 gene differs among species | Papio sp. | - |
| additional information | the tissue-specific expression pattern of the CYP17 gene differs among species | Pan troglodytes | - |
| additional information | the tissue-specific expression pattern of the CYP17 gene differs among species. The human mRNA appears to be ubiquitously expressed in all tissues,with the highest levels detected in testis and adrenals, and also in various human fetal tissues. The enzyme occurs in steroidogenic cells | Homo sapiens | - |
| ovary | - |
Homo sapiens | - |
| testis | - |
Homo sapiens | - |
| testis | highest expression | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
17alpha-hydroxylase and 17,20-lyase activities of purified enzyme, comparisons of different species, overview | Cavia porcellus |
| additional information | - |
17alpha-hydroxylase and 17,20-lyase activities of purified enzyme, comparisons of different species, overview | Mus musculus |
| additional information | - |
17alpha-hydroxylase and 17,20-lyase activities of purified enzyme, comparisons of different species, overview | Rattus norvegicus |
| additional information | - |
17alpha-hydroxylase and 17,20-lyase activities of purified enzyme, comparisons of different species, overview | Sus scrofa |
| additional information | - |
17alpha-hydroxylase and 17,20-lyase activities of purified enzyme, comparisons of different species, overview | Bos taurus |
| additional information | - |
17alpha-hydroxylase and 17,20-lyase activities of purified enzyme, comparisons of different species, overview | Ovis aries |
| additional information | - |
17alpha-hydroxylase and 17,20-lyase activities of purified enzyme, comparisons of different species, overview | Felis catus |
| additional information | - |
17alpha-hydroxylase and 17,20-lyase activities of purified enzyme, comparisons of different species, overview | Capra hircus |
| additional information | - |
17alpha-hydroxylase and 17,20-lyase activities of purified enzyme, comparisons of different species, overview | Equus caballus |
| additional information | - |
17alpha-hydroxylase and 17,20-lyase activities of purified enzyme, comparisons of different species, overview | Bison bison |
| additional information | - |
17alpha-hydroxylase and 17,20-lyase activities of purified enzyme, comparisons of different species, overview | Papio sp. |
| additional information | - |
17alpha-hydroxylase and 17,20-lyase activities of purified enzyme, comparisons of different species, overview | Pan troglodytes |
| additional information | - |
17alpha-hydroxylase and 17,20-lyase activities of purified enzyme, comparisons of different species, overview | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 17alpha-hydroxypregnenolone + AH2 + O2 | - |
Cavia porcellus | dehydroepiandrosterone + acetate + A + H2O | - |
? | |
| 17alpha-hydroxypregnenolone + AH2 + O2 | - |
Mus musculus | dehydroepiandrosterone + acetate + A + H2O | - |
? | |
| 17alpha-hydroxypregnenolone + AH2 + O2 | - |
Rattus norvegicus | dehydroepiandrosterone + acetate + A + H2O | - |
? | |
| 17alpha-hydroxypregnenolone + AH2 + O2 | - |
Felis catus | dehydroepiandrosterone + acetate + A + H2O | - |
? | |
| 17alpha-hydroxypregnenolone + AH2 + O2 | - |
Bison bison | dehydroepiandrosterone + acetate + A + H2O | - |
? | |
| 17alpha-hydroxypregnenolone + AH2 + O2 | - |
Papio sp. | dehydroepiandrosterone + acetate + A + H2O | - |
? | |
| 17alpha-hydroxypregnenolone + AH2 + O2 | - |
Pan troglodytes | dehydroepiandrosterone + acetate + A + H2O | - |
? | |
| 17alpha-hydroxypregnenolone + AH2 + O2 | - |
Homo sapiens | dehydroepiandrosterone + acetate + A + H2O | - |
? | |
| 7,12-dimethylbenz[a]anthracene + AH2 + O2 | substrate for CYP17A1 | Homo sapiens | ? | - |
? | |
| 7-dehydro-17alpha-hydroxypregnenolone + AH2 + O2 | low activity | Homo sapiens | 7-dehydro-dehydroepiandrosterone + acetate + A + H2O | - |
? | |
| 7-dehydro-pregnenolone + AH2 + O2 | - |
Homo sapiens | 7-dehydro-17alpha-hydroxy-pregnenolone + A + H2O | - |
? | |
| 7-dehydro-pregnenolone + AH2 + O2 | - |
Bos taurus | 7-dehydro-17alpha-hydroxypregnenolone + A + H2O | - |
? | |
| 7-dehydro-pregnenolone + AH2 + O2 | - |
Ovis aries | 7-dehydro-17alpha-hydroxypregnenolone + A + H2O | - |
? | |
| 7-dehydro-pregnenolone + AH2 + O2 | - |
Capra hircus | 7-dehydro-17alpha-hydroxypregnenolone + A + H2O | - |
? | |
| 7-dehydro-pregnenolone + AH2 + O2 | - |
Homo sapiens | 7-dehydro-17alpha-hydroxypregnenolone + A + H2O | - |
? | |
| aflatoxin B1 + AH2 + O2 | substrate for CYP17A1 | Homo sapiens | aflatoxin B1epoxide + A + H2O | - |
? | |
| additional information | substrate specificity, comparison of different species, overview | Mus musculus | ? | - |
? | |
| additional information | the baboon enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview | Papio sp. | ? | - |
? | |
| additional information | the bison enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview | Bison bison | ? | - |
? | |
| additional information | the bovine enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview | Bos taurus | ? | - |
? | |
| additional information | the cat enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview | Felis catus | ? | - |
? | |
| additional information | the chimp enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview | Pan troglodytes | ? | - |
? | |
| additional information | the goat enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview | Capra hircus | ? | - |
? | |
| additional information | the guinea pig enzyme belongs to the DELTA4-type CYP17, which has no, or very low, 17,20-lyase activity with 17alpha-hydroxy-pregnenolone with the formation of dehydroepiandrosterone, substrate specificity, comparison of different species, overview | Cavia porcellus | ? | - |
? | |
| additional information | the horse enzyme belongs to the DELTA4,5-type of CYP17, which catalyses the 17alpha-hydroxylation of progesterone and pregnenolone and the 17,20-lyase reaction of 17alpha-hydroxy-progesterone and 17alpha-hydroxy-pregnenolone, substrate specificity, comparison of different species, overview | Equus caballus | ? | - |
? | |
| additional information | the human enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview | Homo sapiens | ? | - |
? | |
| additional information | the pig enzyme belongs to the DELTA4,5-type of CYP17, which catalyses the 17alpha-hydroxylation of progesterone and pregnenolone and the 17,20-lyase reaction of 17alpha-hydroxy-progesterone and 17alpha-hydroxy-pregnenolone, substrate specificity, comparison of different species, overview | Sus scrofa | ? | - |
? | |
| additional information | the rat enzyme belongs to the DELTA4,5-type of CYP17, which catalyses the 17alpha-hydroxylation of progesterone and pregnenolone and the 17,20-lyase reaction of 17alpha-hydroxy-progesterone and 17alpha-hydroxy-pregnenolone, substrate specificity, comparison of different species, overview | Rattus norvegicus | ? | - |
? | |
| additional information | the sheep enzyme belongs to the DELTA5-type CYP17, which has no, or very low, 17,20-lyase activity with 17-OH-progesterone with the formation of androstendione, substrate specificity, comparison of different species, none of the primate enzymes has 17,20-lyase activity towards DELTA4-steroids, overview | Ovis aries | ? | - |
? | |
| additional information | CYP17 has both 17alpha-hydroxylase and 17,20-lyase activities | Homo sapiens | ? | - |
? | |
| additional information | no activity with 17alpha-hydroxyprogesterone | Homo sapiens | ? | - |
? | |
| pregnenolone + AH2 + O2 | - |
Homo sapiens | 17alpha-hydroxypregnenolone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | - |
Cavia porcellus | 17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | - |
Mus musculus | 17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | - |
Rattus norvegicus | 17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | - |
Sus scrofa | 17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | - |
Bos taurus | 17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | - |
Ovis aries | 17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | - |
Felis catus | 17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | - |
Capra hircus | 17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | - |
Equus caballus | 17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | - |
Bison bison | 17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | - |
Papio sp. | 17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | - |
Pan troglodytes | 17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + AH2 + O2 | - |
Homo sapiens | 17alpha-hydroxyprogesterone + A + H2O | - |
? | |
| progesterone + reduced acceptor + O2 | - |
Homo sapiens | 17alpha-hydroxyprogesterone + acceptor + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP17 | - |
Cavia porcellus |
| CYP17 | - |
Mus musculus |
| CYP17 | - |
Rattus norvegicus |
| CYP17 | - |
Sus scrofa |
| CYP17 | - |
Bos taurus |
| CYP17 | - |
Ovis aries |
| CYP17 | - |
Felis catus |
| CYP17 | - |
Capra hircus |
| CYP17 | - |
Equus caballus |
| CYP17 | - |
Bison bison |
| CYP17 | - |
Papio sp. |
| CYP17 | - |
Pan troglodytes |
| CYP17 | - |
Homo sapiens |
| CYP17A1 | - |
Homo sapiens |
| CYP17A1 | isoform | Homo sapiens |
| steroid 17alphahydroxylase/17,20-lyase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cytochrome b5 | without effect on steroid 17alpha-hydroxylation, cytochrome b5 causes a 5-10fold stimulation of the 17,20-lyase reaction mediated by CYP17 | Homo sapiens |
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Release 2023.1 (January 2023)
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