Literature summary for 1.14.14.32 extracted from

W�lfling, J.; Oravecz, E.A.; Ondr�, D.; Merny�k, E.; Schneider, G.; T�th, I.; Sz�csi, M.; Julesz, J.
Stereoselective synthesis of some 17beta-dihydrooxazinyl steroids, as novel presumed inhibitors of 17alpha-hydroxylase-C17,20-lyase (2006), Steroids, 71, 809-816.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(3beta,17beta)-17-[2-(4-chlorophenyl)-5,6-dihydro-4H-1,3-oxazin-4-yl]androst-5-en-3-ol	decreases enzyme activity by 70% at 50 µM	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	Wistar rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
testis	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2	-	Rattus norvegicus	androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Synonyms

Synonyms	Comment	Organism
17alpha-hydroxylase-C17,20-lyase	-	Rattus norvegicus

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Release 2023.1 (January 2023)