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Literature summary for 1.14.14.32 extracted from
- Dehydroepiandrosterone formation is independent of cytochrome P450 17alpha-hydroxylase/17, 20 lyase activity in the mouse brain (2009), J. Steroid Biochem. Mol. Biol., 115, 86-90.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| SU10603 | CYP17 chimeric mouse brains incubated in the presence of SU10603, do not form dehydroepiandrosterone | Mus musculus |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 54000 | - |
immunoblot analysis | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
C57BL/6 mice | - |
| Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| testis | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP17 | - |
Mus musculus |
| cytochrome P450 17alpha-hydroxylase/17,20-lyase | - |
Mus musculus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | CYP17 mRNA levels are reduced by 50% in CYP17 chimeric compared to wild-type mouse brain, whereas the levels of brain dehydroepiandrosterone levels are comparable | down |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | no detectable differences in cognitive spatial learning between CYP17 chimeric and wild-type mice. Serum testosterone levels are reduced by 65% in the chimeric mice. Adult mouse brain dehydroepiandrosterone is formed via a Fe2+-sensitive CYP17-independent pathway | Mus musculus |
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