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Literature summary for 1.14.14.32 extracted from

  • Ahmed, S.; Shahid, I.; Dhanani, S.; Owen, C.P.
    Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17alpha-hydroxylase/17,20-lyase (P-450(17alpha)) (2009), Bioorg. Med. Chem. Lett., 19, 4698-4701.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-(1H-imidazol-1-ylmethyl)phenyl 4-(trifluoromethyl)benzenesulfonate
-
Rattus norvegicus
4-(1H-imidazol-1-ylmethyl)phenyl 4-bromobenzenesulfonate
-
Rattus norvegicus
4-(1H-imidazol-1-ylmethyl)phenyl 4-chlorobenzenesulfonate
-
Rattus norvegicus
4-(1H-imidazol-1-ylmethyl)phenyl 4-fluorobenzenesulfonate
-
Rattus norvegicus
4-(1H-imidazol-1-ylmethyl)phenyl 4-iodobenzenesulfonate
-
Rattus norvegicus
4-(1H-imidazol-1-ylmethyl)phenyl 4-methoxybenzenesulfonate
-
Rattus norvegicus
4-(1H-imidazol-1-ylmethyl)phenyl 4-nitrobenzenesulfonate
-
Rattus norvegicus
4-(1H-imidazol-1-ylmethylphenyl)-4-toluenesulfonate
-
Rattus norvegicus
4-iodobenzyl imidazole
-
Rattus norvegicus
ketoconazole
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2
-
Rattus norvegicus androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

Synonyms Comment Organism
17,20 lyase
-
Rattus norvegicus
17alpha-hydroxylase/17,20-lyase
-
Rattus norvegicus
P-45017alpha
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000651
-
at 37°C Rattus norvegicus 4-(1H-imidazol-1-ylmethyl)phenyl 4-iodobenzenesulfonate
0.0000704
-
at 37°C Rattus norvegicus 4-(1H-imidazol-1-ylmethyl)phenyl 4-bromobenzenesulfonate
0.000085
-
at 37°C Rattus norvegicus 4-(1H-imidazol-1-ylmethyl)phenyl 4-nitrobenzenesulfonate
0.0000987
-
at 37°C Rattus norvegicus 4-(1H-imidazol-1-ylmethyl)phenyl 4-chlorobenzenesulfonate
0.0001009
-
at 37°C Rattus norvegicus 4-(1H-imidazol-1-ylmethyl)phenyl 4-methoxybenzenesulfonate
0.00021
-
at 37°C Rattus norvegicus 4-(1H-imidazol-1-ylmethyl)phenyl 4-fluorobenzenesulfonate
0.00023
-
at 37°C Rattus norvegicus 4-(1H-imidazol-1-ylmethylphenyl)-4-toluenesulfonate
0.0002908
-
at 37°C Rattus norvegicus 4-(1H-imidazol-1-ylmethyl)phenyl 4-(trifluoromethyl)benzenesulfonate
0.00158
-
at 37°C Rattus norvegicus 4-iodobenzyl imidazole
0.00166
-
at 37°C Rattus norvegicus ketoconazole