Application | Comment | Organism |
---|---|---|
medicine | inhibition of 17alpha-hydroxylase-C(17,20)-lyase can block androgen synthesis at an early stage, and may therefore be useful in the treatment of prostatic carcinoma | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
17beta-(2-oxazolidon-5-yl)-androst-4-en-3-one | - |
Rattus norvegicus | |
17beta-(2-oxazolidon-5-yl)androst-5-en-3beta-ol | - |
Rattus norvegicus | |
17beta-[3-(N-3,5-dimethylphenyl)-2-oxazolidon-5-yl]androst-4-en-3-one | - |
Rattus norvegicus | |
17beta-[3-(N-3,5-dimethylphenyl)-2-oxazolidon-5-yl]androst-5-en-3beta-ol | - |
Rattus norvegicus | |
17beta-[3-(N-4-bromophenyl)-2-oxazolidon-5-yl]androst-4-en-3-one | - |
Rattus norvegicus | |
17beta-[3-(N-4-bromophenyl)-2-oxazolidon-5-yl]androst-5-en-3beta-ol | - |
Rattus norvegicus | |
17beta-[3-(N-4-chlorophenyl)-2-oxazolidon-5-yl]androst-4-en-3-one | - |
Rattus norvegicus | |
17beta-[3-(N-4-chlorophenyl)-2-oxazolidon-5-yl]androst-5-en-3beta-ol | - |
Rattus norvegicus | |
17beta-[3-(N-4-fluorophenyl)-2-oxazolidon-5-yl]androst-4-en-3-one | - |
Rattus norvegicus | |
17beta-[3-(N-4-fluorophenyl)-2-oxazolidon-5-yl]androst-5-en-3beta-ol | - |
Rattus norvegicus | |
17beta-[3-(N-4-methoxyphenyl)-2-oxazolidon-5-yl]androst-4-en-3-one | - |
Rattus norvegicus | |
17beta-[3-(N-4-methoxyphenyl)-2-oxazolidon-5-yl]androst-5-en-3beta-ol | - |
Rattus norvegicus | |
17beta-[3-(N-phenyl)-2-oxazolidon-5-yl]androst-4-en-3-one | - |
Rattus norvegicus | |
17beta-[3-(N-phenyl)-2-oxazolidon-5-yl]androst-5-en-3beta-ol | - |
Rattus norvegicus | |
3beta-acetoxy-21-chloropregn-5-ene-20beta-N-phenylurethane | - |
Rattus norvegicus | |
abiraterone | i.e. 17-(3-pyridyl)androsta-5,16-dien-3beta-ol | Rattus norvegicus | |
ketoconazole | - |
Rattus norvegicus | |
additional information | inhibitor development and synthesis, inhibitory potencies of compounds, overview | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Rattus norvegicus | - |
Wistar rat | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
testis | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17alpha-hydroxylase-C(17,20)-lyase | - |
Rattus norvegicus |
P45017alpha | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
lyase activity assay | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00075 | - |
- |
Rattus norvegicus | ketoconazole | |
0.003 | - |
- |
Rattus norvegicus | 17beta-(2-oxazolidon-5-yl)-androst-4-en-3-one |