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Literature summary for 1.14.14.32 extracted from
- Mitochondrial metabolism of 17alpha-hydroxyprogesterone in male sea bass (Dicentrarchus labrax): a potential target for endocrine disruptors (2007), Aquat. Toxicol., 85, 258-266.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-nonylphenol | strong inhibitory effect at 0.1 mM | Dicentrarchus labrax |  |
| ketoconazole | strong inhibitory effect at 0.1 mM | Dicentrarchus labrax | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Dicentrarchus labrax | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Dicentrarchus labrax | - |
sea bass | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Dicentrarchus labrax | androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| C17,20-lyase | - |
Dicentrarchus labrax |
| CYP17 | - |
Dicentrarchus labrax |
| P450c17 | - |
Dicentrarchus labrax |
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