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Literature summary for 1.14.14.32 extracted from
- Kinetic analysis of duodenal and testicular cytochrome P450c17 in the rat (1996), J. Steroid Biochem. Mol. Biol., 58, 577-584.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| estradiol-17beta | concentration of 0.3 mM both, testicular and male duodenal enzyme with exogenous 17alpha-hydroxyprogesterone as substrate are inhibited by 30-40% | Rattus norvegicus |  |
| ketoconazole | competitve | Rattus norvegicus | |
| Promegestone | competitive | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000015 | - |
17alpha-hydroxyprogesterone | intermediate substrate, testis enzyme | Rattus norvegicus | |
| 0.0000248 | - |
17alpha-hydroxyprogesterone | intermediate substrate, female duodenum enzyme | Rattus norvegicus | |
| 0.0000314 | - |
17alpha-hydroxyprogesterone | intermediate substrate, male duodenum enzyme | Rattus norvegicus | |
| 0.000525 | - |
17alpha-hydroxyprogesterone | exogenous substrate, testis enzyme | Rattus norvegicus | |
| 0.000637 | - |
17alpha-hydroxyprogesterone | exogenous substrate, female duodenum enzyme | Rattus norvegicus | |
| 0.000675 | - |
17alpha-hydroxyprogesterone | exogenous substrate, male duodenum enzyme | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Wistar rat | - |
| vertebrata | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| duodenum | - |
Rattus norvegicus | - |
| gonad | - |
Rattus norvegicus | - |
| gonad | - |
vertebrata | - |
| liver | - |
Rattus norvegicus | - |
| placenta | - |
Rattus norvegicus | - |
| stomach | - |
Rattus norvegicus | - |
| testis | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 17alpha-Hydroxypregnenolone | - |
Rattus norvegicus | Dehydroepiandrosterone + acetaldehyde | - |
? | |
| 17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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