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Literature summary for 1.14.14.29 extracted from

  • Martin, C.; Bean, R.; Rose, K.; Habib, F.; Seckl, J.
    cyp7b1 catalyses the 7alpha-hydroxylation of dehydroepiandrosterone and 25-hydroxycholesterol in rat prostate (2001), Biochem. J., 355, 509-515.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.29

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001
-
 cholest-5-ene-3beta,25-diol pH 7.4, 37°C Rattus norvegicus
0.004
-
 4-androstene-3,17-dione pH 7.4, 37°C Rattus norvegicus
0.011
-
 17beta-estradiol pH 7.4, 37°C Rattus norvegicus
0.014
-
 dehydroepiandrosterone pH 7.4, 37°C Rattus norvegicus
0.022
-
 5alpha-Androstane-3beta,17beta-diol pH 7.4, 37°C Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell of prostate Rattus norvegicus
-
prostate epithelial cell Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17beta-estradiol + NADPH + H+ + O2
-
 Rattus norvegicus 1,3,5(10)-estratrien-3,7-alpha,17beta-triol + NADP+ + H2O
-
 ?
4-androstene-3,17-dione + NADPH + H+ + O2
-
 Rattus norvegicus 7alpha-hydroxy-4-androstene-3,17-dione + NADP+ + H2O
-
 ?
5alpha-androstane-3beta,17beta-diol + NADPH + H+ + O2
-
 Rattus norvegicus 5alpha,androstane-3beta,7alpha,17beta-triol + NADP+ + H2O
-
 ?
cholest-5-ene-3beta,25-diol + NADPH + H+ + O2
-
 Rattus norvegicus cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
-
 ?
dehydroepiandrosterone + NADPH + H+ + O2
-
 Rattus norvegicus 3beta,7alpha-dihydroxy-5-androsten-17-one + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP7B1
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
cytochrome P-450
-
 Rattus norvegicus
NADPH
-
 Rattus norvegicus